Vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors: a systematic review and meta-analysis
Abstract Objective: Assess survival outcomes and risk of recurrence in vaginal estrogen therapy (VET) users with medical history of breast cancer. Data source: The search strategy was guided by standardized terms and keywords were identified from controlled vocabularies. Following databases were u...
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2025-08-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032025000100309&lng=en&tlng=en |
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| _version_ | 1849240300533317632 |
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| author | Gabriel Moreira Lima Santos Augusto Ostermann Magalhães Pedro do Valle Teichmann Maria Celeste Osório Wender |
| author_facet | Gabriel Moreira Lima Santos Augusto Ostermann Magalhães Pedro do Valle Teichmann Maria Celeste Osório Wender |
| author_sort | Gabriel Moreira Lima Santos |
| collection | DOAJ |
| description | Abstract Objective: Assess survival outcomes and risk of recurrence in vaginal estrogen therapy (VET) users with medical history of breast cancer. Data source: The search strategy was guided by standardized terms and keywords were identified from controlled vocabularies. Following databases were used for literature search: Pubmed, EMBASE, Cochrane, Scopus and Web of Science. Only studies published in the 21st century (2001–present) and written in English were included. Study selection: A total of 988 records were reviewed by two independent authors. After full-text analysis of 38 of them, 7 articles were included in the meta-analysis. Data collection: Data from eligible studies were extracted and tabulated based on predefined criteria: author, country, year, study type, sample size, type of intervention, use of aromatase inhibitors, duration of follow-up, and main outcomes. Results: 118.659 breast cancer survivors were analyzed, of whom 6.358 were treated with VET. The overall analysis showed no significant increase in the risk of recurrence (RR = 0.87, 95%CI: 0.67-1.11). VET users had a significant reduction in all-cause mortality (RR = 0.80, IC95%: 0.75–0,86). Conclusion: Vaginal estrogen therapy appears to be safe in the management of menopausal genitourinary syndrome in breast cancer survivors and it is related to significantly lower all-cause mortality. Prospective Register of Systematic Reviews (PROSPERO): CRD42024602047 |
| format | Article |
| id | doaj-art-6bb0a5cb01514bb890fdb78b484d462d |
| institution | Kabale University |
| issn | 0100-7203 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj-art-6bb0a5cb01514bb890fdb78b484d462d2025-08-20T04:00:39ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032025-08-014710.61622/rbgo/2025rbgo46Vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors: a systematic review and meta-analysisGabriel Moreira Lima Santoshttps://orcid.org/0009-0002-7685-6879Augusto Ostermann Magalhãeshttps://orcid.org/0000-0001-7806-3034Pedro do Valle Teichmannhttps://orcid.org/0000-0003-0617-0927Maria Celeste Osório Wenderhttps://orcid.org/0000-0001-9085-4605Abstract Objective: Assess survival outcomes and risk of recurrence in vaginal estrogen therapy (VET) users with medical history of breast cancer. Data source: The search strategy was guided by standardized terms and keywords were identified from controlled vocabularies. Following databases were used for literature search: Pubmed, EMBASE, Cochrane, Scopus and Web of Science. Only studies published in the 21st century (2001–present) and written in English were included. Study selection: A total of 988 records were reviewed by two independent authors. After full-text analysis of 38 of them, 7 articles were included in the meta-analysis. Data collection: Data from eligible studies were extracted and tabulated based on predefined criteria: author, country, year, study type, sample size, type of intervention, use of aromatase inhibitors, duration of follow-up, and main outcomes. Results: 118.659 breast cancer survivors were analyzed, of whom 6.358 were treated with VET. The overall analysis showed no significant increase in the risk of recurrence (RR = 0.87, 95%CI: 0.67-1.11). VET users had a significant reduction in all-cause mortality (RR = 0.80, IC95%: 0.75–0,86). Conclusion: Vaginal estrogen therapy appears to be safe in the management of menopausal genitourinary syndrome in breast cancer survivors and it is related to significantly lower all-cause mortality. Prospective Register of Systematic Reviews (PROSPERO): CRD42024602047http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032025000100309&lng=en&tlng=enEstrogen replacement therapyEstrogensHormone replacement therapyMenopauseGenitourinary syndromeCancer survivorsBreast neoplasms |
| spellingShingle | Gabriel Moreira Lima Santos Augusto Ostermann Magalhães Pedro do Valle Teichmann Maria Celeste Osório Wender Vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors: a systematic review and meta-analysis Revista Brasileira de Ginecologia e Obstetrícia Estrogen replacement therapy Estrogens Hormone replacement therapy Menopause Genitourinary syndrome Cancer survivors Breast neoplasms |
| title | Vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors: a systematic review and meta-analysis |
| title_full | Vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors: a systematic review and meta-analysis |
| title_fullStr | Vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors: a systematic review and meta-analysis |
| title_full_unstemmed | Vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors: a systematic review and meta-analysis |
| title_short | Vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors: a systematic review and meta-analysis |
| title_sort | vaginal estrogen therapy for treatment of menopausal genitourinary syndrome among breast cancer survivors a systematic review and meta analysis |
| topic | Estrogen replacement therapy Estrogens Hormone replacement therapy Menopause Genitourinary syndrome Cancer survivors Breast neoplasms |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032025000100309&lng=en&tlng=en |
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