Development and validation of prognostic nomogram for overall survival in canine multicentric lymphoma: a retrospective study
Abstract This study aimed to develop and validate prognostic nomogram for predicting 3-month, 6-month, and 12-month overall survival in canine multicentric lymphoma. A total of 163 cases from January 2019 to December 2024 were used as a training set, and 50 cases from January 2017 to January 2019 se...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | BMC Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12917-025-04857-y |
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| Summary: | Abstract This study aimed to develop and validate prognostic nomogram for predicting 3-month, 6-month, and 12-month overall survival in canine multicentric lymphoma. A total of 163 cases from January 2019 to December 2024 were used as a training set, and 50 cases from January 2017 to January 2019 served as a validation set. Predictors were identified using LASSO regression and univariate/multivariate Cox regression analyses, leading to the development of the nomogram: ATRAS2, incorporating age, red blood cell count at diagnosis, changes in red blood cell count after chemotherapy, and albumin-to-globulin ratio. Internal validation showed areas under the receiver operating characteristic curve for ATRAS2 of 0.991, 0.932, and 0.919 for 3-month, 6-month, and 1-year overall survival, respectively. Temporal validation yielded concordance indices of 0.708, 0.701 and 0.783 for 3-month, 6-month, and 1-year overall survival with calibration plots demonstrating strong agreement between predicted and observed overall survival. Decision curve analysis further confirmed the clinical utility of both models for 3-month, 6-month, and 12-month overall survival. The nomogram offers a tool for personalized survival evaluation of canine multicentric lymphoma. |
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| ISSN: | 1746-6148 |