Effectiveness of Intravenous Immunoglobulin for Management of Pain in Patients with Postpolio Syndrome
Objective. Many patients with postpolio syndrome (PPS) experience pain. In this study, we aimed to review previous studies to investigate the effectiveness of intravenous immunoglobulin (IVIG) for managing pain in patients with PPS. We performed a narrative review. Methods. In PubMed, we searched fo...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2021/6637705 |
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| _version_ | 1832550561082245120 |
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| author | Min Cheol Chang Jin-Sung Park Jong-moon Hwang Donghwi Park |
| author_facet | Min Cheol Chang Jin-Sung Park Jong-moon Hwang Donghwi Park |
| author_sort | Min Cheol Chang |
| collection | DOAJ |
| description | Objective. Many patients with postpolio syndrome (PPS) experience pain. In this study, we aimed to review previous studies to investigate the effectiveness of intravenous immunoglobulin (IVIG) for managing pain in patients with PPS. We performed a narrative review. Methods. In PubMed, we searched for the keywords ((Immunoglobulin OR IVIG) AND (poliomyelitis OR poliomyelitis syndrome)). We included articles in which IVIG was infused in patients with PPS and pain severity was measured before and after treatment. Results. In the results, five articles (4 randomized controlled trials and 1 prospective observational study) were included in this review. Four of the studies reported that IVIG had a positive pain-reducing effect in patients with PPS. In addition, 4 studies evaluated the outcomes related to muscle strength and function. Of these studies, 3 showed some improvement in measurements for muscle strength and function. Conclusion. In conclusion, IVIG might be one of the beneficial options for managing pain in PPS. Pain reduction might be responsible for the improvement of muscle strength or function. To confirm the benefits of IVIG in reducing pain, more high-quality studies are required. |
| format | Article |
| id | doaj-art-6ba802067946404f8f0ef431ff203c88 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-6ba802067946404f8f0ef431ff203c882025-02-03T06:06:29ZengWileyPain Research and Management1203-67651918-15232021-01-01202110.1155/2021/66377056637705Effectiveness of Intravenous Immunoglobulin for Management of Pain in Patients with Postpolio SyndromeMin Cheol Chang0Jin-Sung Park1Jong-moon Hwang2Donghwi Park3Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Daegu, Republic of KoreaDepartment of Neurology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of KoreaDepartment of Rehabilitation Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of KoreaDepartment of Physical Medicine and Rehabilitation, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of KoreaObjective. Many patients with postpolio syndrome (PPS) experience pain. In this study, we aimed to review previous studies to investigate the effectiveness of intravenous immunoglobulin (IVIG) for managing pain in patients with PPS. We performed a narrative review. Methods. In PubMed, we searched for the keywords ((Immunoglobulin OR IVIG) AND (poliomyelitis OR poliomyelitis syndrome)). We included articles in which IVIG was infused in patients with PPS and pain severity was measured before and after treatment. Results. In the results, five articles (4 randomized controlled trials and 1 prospective observational study) were included in this review. Four of the studies reported that IVIG had a positive pain-reducing effect in patients with PPS. In addition, 4 studies evaluated the outcomes related to muscle strength and function. Of these studies, 3 showed some improvement in measurements for muscle strength and function. Conclusion. In conclusion, IVIG might be one of the beneficial options for managing pain in PPS. Pain reduction might be responsible for the improvement of muscle strength or function. To confirm the benefits of IVIG in reducing pain, more high-quality studies are required.http://dx.doi.org/10.1155/2021/6637705 |
| spellingShingle | Min Cheol Chang Jin-Sung Park Jong-moon Hwang Donghwi Park Effectiveness of Intravenous Immunoglobulin for Management of Pain in Patients with Postpolio Syndrome Pain Research and Management |
| title | Effectiveness of Intravenous Immunoglobulin for Management of Pain in Patients with Postpolio Syndrome |
| title_full | Effectiveness of Intravenous Immunoglobulin for Management of Pain in Patients with Postpolio Syndrome |
| title_fullStr | Effectiveness of Intravenous Immunoglobulin for Management of Pain in Patients with Postpolio Syndrome |
| title_full_unstemmed | Effectiveness of Intravenous Immunoglobulin for Management of Pain in Patients with Postpolio Syndrome |
| title_short | Effectiveness of Intravenous Immunoglobulin for Management of Pain in Patients with Postpolio Syndrome |
| title_sort | effectiveness of intravenous immunoglobulin for management of pain in patients with postpolio syndrome |
| url | http://dx.doi.org/10.1155/2021/6637705 |
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