Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition.

Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition.

mTOR inhibitors are used clinically to treat renal cancer but are not curative. Here we show that autophagy is a resistance mechanism of human renal cell carcinoma (RCC) cell lines to mTOR inhibitors. RCC cell lines have high basal autophagy that is required for survival to mTOR inhibition. In RCC4...

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Main Authors: Kevin Bray, Robin Mathew, Alexandria Lau, Jurre J Kamphorst, Jing Fan, Jim Chen, Hsin-Yi Chen, Anahita Ghavami, Mark Stein, Robert S DiPaola, Donna Zhang, Joshua D Rabinowitz, Eileen White
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0041831
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