From Molecules to Mind: The Critical Role of Chitosan, Collagen, Alginate, and Other Biopolymers in Neuroprotection and Neurodegeneration
Neurodegenerative disorders present significant therapeutic challenges, particularly due to the complex nature of drug delivery to the central nervous system. This review investigates the applications of various biopolymers in neuroprotection and their potential role in treating neurodegeneration. W...
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MDPI AG
2025-02-01
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| Online Access: | https://www.mdpi.com/1420-3049/30/5/1017 |
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| author | Weronika Kruczkowska Julia Gałęziewska Katarzyna Helena Grabowska Piotr Gromek Karolina Czajkowska Maciej Rybicki Mateusz Kciuk Karol Kamil Kłosiński |
| author_facet | Weronika Kruczkowska Julia Gałęziewska Katarzyna Helena Grabowska Piotr Gromek Karolina Czajkowska Maciej Rybicki Mateusz Kciuk Karol Kamil Kłosiński |
| author_sort | Weronika Kruczkowska |
| collection | DOAJ |
| description | Neurodegenerative disorders present significant therapeutic challenges, particularly due to the complex nature of drug delivery to the central nervous system. This review investigates the applications of various biopolymers in neuroprotection and their potential role in treating neurodegeneration. We present a critical analysis of natural and synthetic biopolymers, focusing primarily on chitosan, fish collagen/gelatin, and alginate as key therapeutic agents. The review examines the fundamental mechanisms of brain development and neurodegeneration, establishing a framework for understanding how these biopolymers interact with neural tissues. By analyzing recent experimental studies, we evaluate the effectiveness of different biopolymer-based delivery systems in crossing the blood–brain barrier and their subsequent neuroprotective effects. Additionally, promising materials, including lignin, poly lactic-co-glycolic acid, and glucose-modified bovine serum albumin/procyanidin complexes, are briefly explored to provide a comprehensive overview of current developments in the field. Our analysis reveals that biopolymer-based approaches offer unique advantages in both neuroprotection and drug delivery, potentially opening new avenues for treating neurodegenerative conditions. This review synthesizes current knowledge and identifies promising directions for future research in biopolymer-based therapeutic strategies. |
| format | Article |
| id | doaj-art-6ba1ed5fd85f4ca4be2cf254aee580a0 |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-6ba1ed5fd85f4ca4be2cf254aee580a02025-08-20T02:59:15ZengMDPI AGMolecules1420-30492025-02-01305101710.3390/molecules30051017From Molecules to Mind: The Critical Role of Chitosan, Collagen, Alginate, and Other Biopolymers in Neuroprotection and NeurodegenerationWeronika Kruczkowska0Julia Gałęziewska1Katarzyna Helena Grabowska2Piotr Gromek3Karolina Czajkowska4Maciej Rybicki5Mateusz Kciuk6Karol Kamil Kłosiński7Department of Functional Genomics, Faculty of Medicine, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Functional Genomics, Faculty of Medicine, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Functional Genomics, Faculty of Medicine, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Functional Genomics, Faculty of Medicine, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Biomedicine and Experimental Surgery, Faculty of Medicine, Medical University of Lodz, Narutowicza 60, 90-136 Lodz, PolandDepartment of Biomedicine and Experimental Surgery, Faculty of Medicine, Medical University of Lodz, Narutowicza 60, 90-136 Lodz, PolandDepartment of Molecular Biotechnology and Genetics, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Biomedicine and Experimental Surgery, Faculty of Medicine, Medical University of Lodz, Narutowicza 60, 90-136 Lodz, PolandNeurodegenerative disorders present significant therapeutic challenges, particularly due to the complex nature of drug delivery to the central nervous system. This review investigates the applications of various biopolymers in neuroprotection and their potential role in treating neurodegeneration. We present a critical analysis of natural and synthetic biopolymers, focusing primarily on chitosan, fish collagen/gelatin, and alginate as key therapeutic agents. The review examines the fundamental mechanisms of brain development and neurodegeneration, establishing a framework for understanding how these biopolymers interact with neural tissues. By analyzing recent experimental studies, we evaluate the effectiveness of different biopolymer-based delivery systems in crossing the blood–brain barrier and their subsequent neuroprotective effects. Additionally, promising materials, including lignin, poly lactic-co-glycolic acid, and glucose-modified bovine serum albumin/procyanidin complexes, are briefly explored to provide a comprehensive overview of current developments in the field. Our analysis reveals that biopolymer-based approaches offer unique advantages in both neuroprotection and drug delivery, potentially opening new avenues for treating neurodegenerative conditions. This review synthesizes current knowledge and identifies promising directions for future research in biopolymer-based therapeutic strategies.https://www.mdpi.com/1420-3049/30/5/1017alginatebiopolymerschitosancollagenneurodegenerationneuroprotection |
| spellingShingle | Weronika Kruczkowska Julia Gałęziewska Katarzyna Helena Grabowska Piotr Gromek Karolina Czajkowska Maciej Rybicki Mateusz Kciuk Karol Kamil Kłosiński From Molecules to Mind: The Critical Role of Chitosan, Collagen, Alginate, and Other Biopolymers in Neuroprotection and Neurodegeneration Molecules alginate biopolymers chitosan collagen neurodegeneration neuroprotection |
| title | From Molecules to Mind: The Critical Role of Chitosan, Collagen, Alginate, and Other Biopolymers in Neuroprotection and Neurodegeneration |
| title_full | From Molecules to Mind: The Critical Role of Chitosan, Collagen, Alginate, and Other Biopolymers in Neuroprotection and Neurodegeneration |
| title_fullStr | From Molecules to Mind: The Critical Role of Chitosan, Collagen, Alginate, and Other Biopolymers in Neuroprotection and Neurodegeneration |
| title_full_unstemmed | From Molecules to Mind: The Critical Role of Chitosan, Collagen, Alginate, and Other Biopolymers in Neuroprotection and Neurodegeneration |
| title_short | From Molecules to Mind: The Critical Role of Chitosan, Collagen, Alginate, and Other Biopolymers in Neuroprotection and Neurodegeneration |
| title_sort | from molecules to mind the critical role of chitosan collagen alginate and other biopolymers in neuroprotection and neurodegeneration |
| topic | alginate biopolymers chitosan collagen neurodegeneration neuroprotection |
| url | https://www.mdpi.com/1420-3049/30/5/1017 |
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