Rational Design of Inner Ear Drug Delivery Systems
Abstract The number of people with hearing loss disorders is enormous, causing great physical and mental stress to patients, as well as a huge social burden. Among these patients, hearing loss caused by inner ear lesions accounts for a large proportion. Therefore, treatment of the inner ear is impor...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-08-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202410568 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850034270327799808 |
|---|---|
| author | Xiayidan Maimaitikelimu Zhiyan Xuan Haoyu Ren Keng Chen Hui Zhang Huan Wang |
| author_facet | Xiayidan Maimaitikelimu Zhiyan Xuan Haoyu Ren Keng Chen Hui Zhang Huan Wang |
| author_sort | Xiayidan Maimaitikelimu |
| collection | DOAJ |
| description | Abstract The number of people with hearing loss disorders is enormous, causing great physical and mental stress to patients, as well as a huge social burden. Among these patients, hearing loss caused by inner ear lesions accounts for a large proportion. Therefore, treatment of the inner ear is important. Inner ear drug delivery systems, which can reduce the side effects of systemic drug administration by delivering drugs directly to the inner ear, are important in sensorineural hearing loss. Here, the development of inner ear drug delivery systems is focused, including the complex physiological structure that they face, types of drugs delivered, routes of administration, and forms of drug delivery carrier platforms. Recent studies in this process are presented and it is concluded with a summary and outlook on the problems faced and possible solutions. |
| format | Article |
| id | doaj-art-6b99adf621e54850b9c7f955d72fee09 |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-6b99adf621e54850b9c7f955d72fee092025-08-20T02:57:53ZengWileyAdvanced Science2198-38442025-08-011229n/an/a10.1002/advs.202410568Rational Design of Inner Ear Drug Delivery SystemsXiayidan Maimaitikelimu0Zhiyan Xuan1Haoyu Ren2Keng Chen3Hui Zhang4Huan Wang5The Eighth Affiliated HospitalSun Yat‐Sen UniversityShenzhen518033ChinaThe Eighth Affiliated HospitalSun Yat‐Sen UniversityShenzhen518033ChinaThe Eighth Affiliated HospitalSun Yat‐Sen UniversityShenzhen518033ChinaThe Eighth Affiliated HospitalSun Yat‐Sen UniversityShenzhen518033ChinaSchool of Life Sciences and TechnologySoutheast UniversityNanjing 210000 ChinaThe Eighth Affiliated HospitalSun Yat‐Sen UniversityShenzhen518033ChinaAbstract The number of people with hearing loss disorders is enormous, causing great physical and mental stress to patients, as well as a huge social burden. Among these patients, hearing loss caused by inner ear lesions accounts for a large proportion. Therefore, treatment of the inner ear is important. Inner ear drug delivery systems, which can reduce the side effects of systemic drug administration by delivering drugs directly to the inner ear, are important in sensorineural hearing loss. Here, the development of inner ear drug delivery systems is focused, including the complex physiological structure that they face, types of drugs delivered, routes of administration, and forms of drug delivery carrier platforms. Recent studies in this process are presented and it is concluded with a summary and outlook on the problems faced and possible solutions.https://doi.org/10.1002/advs.202410568drug deliveryhair cellshearing lossinner earphysiologic barriers |
| spellingShingle | Xiayidan Maimaitikelimu Zhiyan Xuan Haoyu Ren Keng Chen Hui Zhang Huan Wang Rational Design of Inner Ear Drug Delivery Systems Advanced Science drug delivery hair cells hearing loss inner ear physiologic barriers |
| title | Rational Design of Inner Ear Drug Delivery Systems |
| title_full | Rational Design of Inner Ear Drug Delivery Systems |
| title_fullStr | Rational Design of Inner Ear Drug Delivery Systems |
| title_full_unstemmed | Rational Design of Inner Ear Drug Delivery Systems |
| title_short | Rational Design of Inner Ear Drug Delivery Systems |
| title_sort | rational design of inner ear drug delivery systems |
| topic | drug delivery hair cells hearing loss inner ear physiologic barriers |
| url | https://doi.org/10.1002/advs.202410568 |
| work_keys_str_mv | AT xiayidanmaimaitikelimu rationaldesignofinnereardrugdeliverysystems AT zhiyanxuan rationaldesignofinnereardrugdeliverysystems AT haoyuren rationaldesignofinnereardrugdeliverysystems AT kengchen rationaldesignofinnereardrugdeliverysystems AT huizhang rationaldesignofinnereardrugdeliverysystems AT huanwang rationaldesignofinnereardrugdeliverysystems |