Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenia in elderly adults
BackgroundThis study aimed to explore the link between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and sarcopenia in elderly adults using data from the National Health and Nutrition Examination Survey (NHANES).MethodsThe dataset from NHANES 1999–2004...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1614263/full |
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| author | Yi Lin Xiaocong Shi Weijia Wu Xiyi Chen |
| author_facet | Yi Lin Xiaocong Shi Weijia Wu Xiyi Chen |
| author_sort | Yi Lin |
| collection | DOAJ |
| description | BackgroundThis study aimed to explore the link between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and sarcopenia in elderly adults using data from the National Health and Nutrition Examination Survey (NHANES).MethodsThe dataset from NHANES 1999–2004. Different statistical analyses, including logistic regression, restricted cubic spline, two-piecewise linear regression, subgroup analyses, and interaction tests models, were used to examine the relationship between NHHR and the risk of sarcopenia.ResultsTotal 3,190 elderly participants were included and 676 (21.2%) of them had sarcopenia. In crude model, the odds ratio (OR) of NHHR on sarcopenia was 0.71 [95% confidence interval (CI), 0.66–0.77]. After adjusting for all factors, the ORs for NHHR tertiles 2 and 3 were 0.76 (95% CI: 0.58–0.99) and 0.70 (95% CI: 0.53–0.94), respectively, with a significant trend (p = 0.014). An L-shaped relationship between NHHR and sarcopenia was found (P for non-linearity = 0.046), with 3.01 being the inflection point. Subgroup analysis results indicated a stable and persistent association between NHHR and sarcopenia across multiple subgroups, with the exception of diabetes.ConclusionWe found that NHHR was negatively associated with risk of sarcopenia in elderly adults. |
| format | Article |
| id | doaj-art-6b97e798825e4e989bf84308e77a2f33 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-6b97e798825e4e989bf84308e77a2f332025-08-20T03:29:15ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-06-011210.3389/fnut.2025.16142631614263Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenia in elderly adultsYi Lin0Xiaocong Shi1Weijia Wu2Xiyi Chen3Department of Endocrinology, The Third Affiliated Hospital of Shanghai University, Wenzhou People’s Hospital, Wenzhou, ChinaDepartment of Endocrinology, The Third Affiliated Hospital of Shanghai University, Wenzhou People’s Hospital, Wenzhou, ChinaDepartment of Cardiovascular and Thoracic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiovascular and Thoracic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaBackgroundThis study aimed to explore the link between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and sarcopenia in elderly adults using data from the National Health and Nutrition Examination Survey (NHANES).MethodsThe dataset from NHANES 1999–2004. Different statistical analyses, including logistic regression, restricted cubic spline, two-piecewise linear regression, subgroup analyses, and interaction tests models, were used to examine the relationship between NHHR and the risk of sarcopenia.ResultsTotal 3,190 elderly participants were included and 676 (21.2%) of them had sarcopenia. In crude model, the odds ratio (OR) of NHHR on sarcopenia was 0.71 [95% confidence interval (CI), 0.66–0.77]. After adjusting for all factors, the ORs for NHHR tertiles 2 and 3 were 0.76 (95% CI: 0.58–0.99) and 0.70 (95% CI: 0.53–0.94), respectively, with a significant trend (p = 0.014). An L-shaped relationship between NHHR and sarcopenia was found (P for non-linearity = 0.046), with 3.01 being the inflection point. Subgroup analysis results indicated a stable and persistent association between NHHR and sarcopenia across multiple subgroups, with the exception of diabetes.ConclusionWe found that NHHR was negatively associated with risk of sarcopenia in elderly adults.https://www.frontiersin.org/articles/10.3389/fnut.2025.1614263/fullNHHRlipidssarcopeniaelderlyNHANES |
| spellingShingle | Yi Lin Xiaocong Shi Weijia Wu Xiyi Chen Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenia in elderly adults Frontiers in Nutrition NHHR lipids sarcopenia elderly NHANES |
| title | Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenia in elderly adults |
| title_full | Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenia in elderly adults |
| title_fullStr | Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenia in elderly adults |
| title_full_unstemmed | Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenia in elderly adults |
| title_short | Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenia in elderly adults |
| title_sort | association of non high density lipoprotein cholesterol to high density lipoprotein cholesterol nhhr and sarcopenia in elderly adults |
| topic | NHHR lipids sarcopenia elderly NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1614263/full |
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