HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS?
Objective: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial disease in which the sinus and nasal mucosa are affected. We investigated the relationship between the genetic polymorphism of MMP 9 (rs17576) and TIMP 1 (rs48498) and serum levels, and we wanted to investigate the e...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Istanbul University Press
2023-03-01
|
| Series: | İstanbul Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/D293F8973D494548A6482302F9BAFEB8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850275996164423680 |
|---|---|
| author | Meltem Bozacı Kılıçoğlu Barış Ertuğrul Göksu Kaşarcı Şenol Çomoğlu Levent Aydemir Meryem Nesil Keleş Türel Aslı Gelincik Bedia Çakmakoğlu |
| author_facet | Meltem Bozacı Kılıçoğlu Barış Ertuğrul Göksu Kaşarcı Şenol Çomoğlu Levent Aydemir Meryem Nesil Keleş Türel Aslı Gelincik Bedia Çakmakoğlu |
| author_sort | Meltem Bozacı Kılıçoğlu |
| collection | DOAJ |
| description | Objective: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial disease in which the sinus and nasal mucosa are affected. We investigated the relationship between the genetic polymorphism of MMP 9 (rs17576) and TIMP 1 (rs48498) and serum levels, and we wanted to investigate the effect of MMP 9 and TIMP 1 genotypes on Vitamin serum levels in CRSwNP with and without Aspirin-Exacerbated Respiratory Disease (AERD). Materials and Methods: This study consisted of 99 patients with CRSwNP with AERD and CRSwNP without AERD. The RT-PCR method and ELISA were used in this study. ELISA was used for MMP 9 and TIMP 1 serum levels and Vitamin D levels. Results: Serum levels of MMP 9 were markedly higher in AG genotype than GG genotype in CRSwNP with AERD. Serum levels of MMP 9 were statistically higher in carrying of A (+) allele in CRSwNP with AERD than in not carrying of A (+) allele. In addition, serum levels of Vitamin D were discovered significantly lower in TIMP 1 CT genotype in comparison to CC and TT genotypes in all of CRSwNP. Conclusion: The rising of MMP 9 serum levels may be a marker of chronic inflammation or they may be a significant factor in theresistance to diseases. This study may lead to a further understanding of disease severity in CRSwNP with AERD. |
| format | Article |
| id | doaj-art-6b8ffc67a549432faf12faf60eb9b7d7 |
| institution | OA Journals |
| issn | 1305-6441 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-6b8ffc67a549432faf12faf60eb9b7d72025-08-20T01:50:27ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412023-03-0186215215810.26650/IUITFD.1210739123456HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS?Meltem Bozacı Kılıçoğlu0https://orcid.org/0000-0001-9952-0329Barış Ertuğrul1https://orcid.org/0000-0003-3878-1829Göksu Kaşarcı2https://orcid.org/0000-0001-9766-4361Şenol Çomoğlu3https://orcid.org/0000-0003-4632-9218Levent Aydemir4https://orcid.org/0000-0002-5836-4304Meryem Nesil Keleş Türel5https://orcid.org/0000-0003-1829-8186Aslı Gelincik6https://orcid.org/0000-0002-3524-9952Bedia Çakmakoğlu7https://orcid.org/0000-0001-7960-9131İstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeObjective: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial disease in which the sinus and nasal mucosa are affected. We investigated the relationship between the genetic polymorphism of MMP 9 (rs17576) and TIMP 1 (rs48498) and serum levels, and we wanted to investigate the effect of MMP 9 and TIMP 1 genotypes on Vitamin serum levels in CRSwNP with and without Aspirin-Exacerbated Respiratory Disease (AERD). Materials and Methods: This study consisted of 99 patients with CRSwNP with AERD and CRSwNP without AERD. The RT-PCR method and ELISA were used in this study. ELISA was used for MMP 9 and TIMP 1 serum levels and Vitamin D levels. Results: Serum levels of MMP 9 were markedly higher in AG genotype than GG genotype in CRSwNP with AERD. Serum levels of MMP 9 were statistically higher in carrying of A (+) allele in CRSwNP with AERD than in not carrying of A (+) allele. In addition, serum levels of Vitamin D were discovered significantly lower in TIMP 1 CT genotype in comparison to CC and TT genotypes in all of CRSwNP. Conclusion: The rising of MMP 9 serum levels may be a marker of chronic inflammation or they may be a significant factor in theresistance to diseases. This study may lead to a further understanding of disease severity in CRSwNP with AERD.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/D293F8973D494548A6482302F9BAFEB8nasal polyposismmp 9timp 1genetic polymorphismchronic rhinosinusitis |
| spellingShingle | Meltem Bozacı Kılıçoğlu Barış Ertuğrul Göksu Kaşarcı Şenol Çomoğlu Levent Aydemir Meryem Nesil Keleş Türel Aslı Gelincik Bedia Çakmakoğlu HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS? İstanbul Tıp Fakültesi Dergisi nasal polyposis mmp 9 timp 1 genetic polymorphism chronic rhinosinusitis |
| title | HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS? |
| title_full | HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS? |
| title_fullStr | HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS? |
| title_full_unstemmed | HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS? |
| title_short | HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS? |
| title_sort | how do the genetic variants of mmp 9 and timp 1 and vitamin d affect chronic rhinosinusitis with nasal polyposis |
| topic | nasal polyposis mmp 9 timp 1 genetic polymorphism chronic rhinosinusitis |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/D293F8973D494548A6482302F9BAFEB8 |
| work_keys_str_mv | AT meltembozacıkılıcoglu howdothegeneticvariantsofmmp9andtimp1andvitamindaffectchronicrhinosinusitiswithnasalpolyposis AT barısertugrul howdothegeneticvariantsofmmp9andtimp1andvitamindaffectchronicrhinosinusitiswithnasalpolyposis AT goksukasarcı howdothegeneticvariantsofmmp9andtimp1andvitamindaffectchronicrhinosinusitiswithnasalpolyposis AT senolcomoglu howdothegeneticvariantsofmmp9andtimp1andvitamindaffectchronicrhinosinusitiswithnasalpolyposis AT leventaydemir howdothegeneticvariantsofmmp9andtimp1andvitamindaffectchronicrhinosinusitiswithnasalpolyposis AT meryemnesilkelesturel howdothegeneticvariantsofmmp9andtimp1andvitamindaffectchronicrhinosinusitiswithnasalpolyposis AT aslıgelincik howdothegeneticvariantsofmmp9andtimp1andvitamindaffectchronicrhinosinusitiswithnasalpolyposis AT bediacakmakoglu howdothegeneticvariantsofmmp9andtimp1andvitamindaffectchronicrhinosinusitiswithnasalpolyposis |