HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS?

HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS?

Objective: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial disease in which the sinus and nasal mucosa are affected. We investigated the relationship between the genetic polymorphism of MMP 9 (rs17576) and TIMP 1 (rs48498) and serum levels, and we wanted to investigate the e...

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Main Authors: Meltem Bozacı Kılıçoğlu, Barış Ertuğrul, Göksu Kaşarcı, Şenol Çomoğlu, Levent Aydemir, Meryem Nesil Keleş Türel, Aslı Gelincik, Bedia Çakmakoğlu
Format: Article
Language:English
Published: Istanbul University Press 2023-03-01
Series:İstanbul Tıp Fakültesi Dergisi
Subjects:
nasal polyposis
mmp 9
timp 1
genetic polymorphism
chronic rhinosinusitis
Online Access:https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/D293F8973D494548A6482302F9BAFEB8
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Summary:Objective: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial disease in which the sinus and nasal mucosa are affected. We investigated the relationship between the genetic polymorphism of MMP 9 (rs17576) and TIMP 1 (rs48498) and serum levels, and we wanted to investigate the effect of MMP 9 and TIMP 1 genotypes on Vitamin serum levels in CRSwNP with and without Aspirin-Exacerbated Respiratory Disease (AERD). Materials and Methods: This study consisted of 99 patients with CRSwNP with AERD and CRSwNP without AERD. The RT-PCR method and ELISA were used in this study. ELISA was used for MMP 9 and TIMP 1 serum levels and Vitamin D levels. Results: Serum levels of MMP 9 were markedly higher in AG genotype than GG genotype in CRSwNP with AERD. Serum levels of MMP 9 were statistically higher in carrying of A (+) allele in CRSwNP with AERD than in not carrying of A (+) allele. In addition, serum levels of Vitamin D were discovered significantly lower in TIMP 1 CT genotype in comparison to CC and TT genotypes in all of CRSwNP. Conclusion: The rising of MMP 9 serum levels may be a marker of chronic inflammation or they may be a significant factor in theresistance to diseases. This study may lead to a further understanding of disease severity in CRSwNP with AERD.
ISSN:1305-6441

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