Effect of Opioid on Adult Hippocampal Neurogenesis
During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid. He...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/2601264 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556678006964224 |
|---|---|
| author | Yue Zhang Horace H. Loh Ping-Yee Law |
| author_facet | Yue Zhang Horace H. Loh Ping-Yee Law |
| author_sort | Yue Zhang |
| collection | DOAJ |
| description | During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid. Here, we review the most recent works on opiate drugs’ effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms. We conclude that opiate drugs in general cause a loss of newly born neural progenitors in the subgranular zone of dentate gyrus, by either modulating proliferation or interfering with differentiation and maturation. We also discuss the consequent impact of regulation of adult neurogenesis in animal’s opioid addiction behavior. We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse. |
| format | Article |
| id | doaj-art-6b82881c9c6b45189db6a35020aaea0c |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6b82881c9c6b45189db6a35020aaea0c2025-02-03T05:44:42ZengWileyThe Scientific World Journal2356-61401537-744X2016-01-01201610.1155/2016/26012642601264Effect of Opioid on Adult Hippocampal NeurogenesisYue Zhang0Horace H. Loh1Ping-Yee Law2Department of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455-0217, USADepartment of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455-0217, USADepartment of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455-0217, USADuring the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid. Here, we review the most recent works on opiate drugs’ effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms. We conclude that opiate drugs in general cause a loss of newly born neural progenitors in the subgranular zone of dentate gyrus, by either modulating proliferation or interfering with differentiation and maturation. We also discuss the consequent impact of regulation of adult neurogenesis in animal’s opioid addiction behavior. We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.http://dx.doi.org/10.1155/2016/2601264 |
| spellingShingle | Yue Zhang Horace H. Loh Ping-Yee Law Effect of Opioid on Adult Hippocampal Neurogenesis The Scientific World Journal |
| title | Effect of Opioid on Adult Hippocampal Neurogenesis |
| title_full | Effect of Opioid on Adult Hippocampal Neurogenesis |
| title_fullStr | Effect of Opioid on Adult Hippocampal Neurogenesis |
| title_full_unstemmed | Effect of Opioid on Adult Hippocampal Neurogenesis |
| title_short | Effect of Opioid on Adult Hippocampal Neurogenesis |
| title_sort | effect of opioid on adult hippocampal neurogenesis |
| url | http://dx.doi.org/10.1155/2016/2601264 |
| work_keys_str_mv | AT yuezhang effectofopioidonadulthippocampalneurogenesis AT horacehloh effectofopioidonadulthippocampalneurogenesis AT pingyeelaw effectofopioidonadulthippocampalneurogenesis |