EZH2 inhibition induces pyroptosis via RHA-mediated S100A9 overexpression in myelodysplastic syndromes

EZH2 inhibition induces pyroptosis via RHA-mediated S100A9 overexpression in myelodysplastic syndromes

Abstract Myelodysplastic Syndromes (MDS) represent a group of heterogeneous myeloid clonal diseases derived from aberrant hematopoietic stem/progenitor cells. Enhancer of zeste homolog 2 (EZH2) is an important regulator in gene expression through methyltransferase-dependent or methyltransferase-inde...

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Main Authors: Qi Zhang, Yingwan Luo, Li Ye, Yuxia Wang, Lu Wang, Wenli Yang, Wei Lang, Shuanghong Zhu, Lingxu Jiang, Weimei Jin, Chen Mei, Xinping Zhou, Yanling Ren, Liya Ma, Gaixiang Xu, Bowatte Gedara Lakmal Vimukthi Bandara Bowattage, Hongyan Tong, Jie Sun
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Experimental Hematology & Oncology
Subjects:
Myelodysplastic syndromes
Enhancer of zeste homologue 2
RNA helicase A
S100 calcium binding protein A9
Pyroptosis
Online Access:https://doi.org/10.1186/s40164-025-00600-3
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https://doi.org/10.1186/s40164-025-00600-3

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