Evaluation of Surveillance System for Adverse Drug Reaction Due to Antiretroviral Drugs, Mazowe District, Zimbabwe, 2021
Introduction: Antiretroviral drugs (ARVs) are associated with the occurrence of adverse drug reactions (ADRs). The Medicines Control Authority of Zimbabwe requires that all ADRs be reported within 15 days of detection. In 2020, only 24% of ARV ADRs in Mazowe District were reported. We evaluated the...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
African Field Epidemiology Network
2025-01-01
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| Series: | Journal of Interventional Epidemiology and Public Health |
| Subjects: | |
| Online Access: | https://www.afenet-journal.net/content/article/8/2/full/ |
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| Summary: | Introduction: Antiretroviral drugs (ARVs) are associated with the occurrence of adverse drug reactions (ADRs). The Medicines Control Authority of Zimbabwe requires that all ADRs be reported within 15 days of detection. In 2020, only 24% of ARV ADRs in Mazowe District were reported. We evaluated the performance of the ARV ADR surveillance system in Mazowe District.
Methods: We conducted a descriptive cross-sectional study using updated United States Centre for Disease Control guidelines. We recruited doctors and nurses managing HIV in health facilities in the district and reviewed all completed ARV ADR forms. Data on reasons for underreporting, knowledge, usefulness, and attributes of the ARV ADR surveillance system were obtained using pre-tested interviewer-administered questionnaires and checklists. We conducted univariate analysis to generate frequencies and proportions.
Results: Of the 81 health workers, 61 (75.3%) were female. Forty-three (53.1%) respondents had poor knowledge of the ADR surveillance system. Two (2.5%) respondents were trained in ADR surveillance. Only eight ADR reporting forms were completed of the 25 ARV ADR cases noted in health facility records. No health facility had records of meetings to discuss ADR data. Reasons for underreporting were perceiving ADRs as minor (58.0%) and having a high workload (55.6%).
Conclusion: There was no evidence of surveillance data utilisation meetings. The health workers lacked training and were not knowledgeable about the surveillance system. We recommended health worker training on ADR surveillance and inclusion of ARV ADR surveillance data analysis and discussions in healthcare institutions’ meetings. |
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| ISSN: | 2664-2824 |