Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System

Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System

Abstract The CRISPR‐Cas12a system has gained significant attention as a rapid nucleic acid diagnostic tool due to its crRNA‐guided trans‐cleavage activity. Accurately predicting the activity of different targets is significant to facilitate the crRNA availability but remains challenging. In this stu...

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Bibliographic Details
Main Authors: Zhihao Yao, Wanglu Li, Kaiyu He, Hongmei Wang, Yan Xu, Qun Wu, Liu Wang, Yao Nie
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
activity prediction
CRISPR‐Cas12a
deep learning
molecular dynamics simulation
trans‐cleavage
Online Access:https://doi.org/10.1002/advs.202501269
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