Hypomagnesemia: exploring its multifaceted health impacts and associations with blood pressure regulation and metabolic syndrome
Abstract This article provides a comprehensive and in-depth exploration of the multifaceted effects of Hypomagnesemia on human health, with a specific focus on its intricate associations with mechanisms regulating blood pressure and metabolic syndrome. Firstly, the fundamental concept of hypomagnese...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-025-01772-y |
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| author | Wenlong Wu Ming Gong Pan Liu Huiying Yu Xue Gao Xin Zhao |
| author_facet | Wenlong Wu Ming Gong Pan Liu Huiying Yu Xue Gao Xin Zhao |
| author_sort | Wenlong Wu |
| collection | DOAJ |
| description | Abstract This article provides a comprehensive and in-depth exploration of the multifaceted effects of Hypomagnesemia on human health, with a specific focus on its intricate associations with mechanisms regulating blood pressure and metabolic syndrome. Firstly, the fundamental concept of hypomagnesemia is elucidated, followed by a detailed analysis of its prevalence, risk factors, and Magnesium Deficiency Score. Furthermore, this article delves into the intricate relationship between hypomagnesemia and blood pressure regulation, encompassing its impact on endothelial function, vascular calcification, oxidative stress and inflammatory response, sympathetic nervous system activity as well as the renin–angiotensin–aldosterone system (RAAS). Additionally, it explores the correlation between hypomagnesemia and insulin resistance, metabolic syndrome along with other health issues. Notably noteworthy is that this paper also places special emphasis on exploring the potential role of hypomagnesemia in specific diseases such as renal hypertension and preeclampsia while providing novel insights for their prevention and treatment. Finally, this article summarizes the diverse effects of hypomagnesemia on health while anticipating future research directions. Future studies should further investigate the pathogenesis underlying hypomagnesemia while optimizing assessment methods for magnesium deficiency to develop targeted intervention strategies aimed at offering improved treatment options alongside preventive measures for patients. |
| format | Article |
| id | doaj-art-6b78debf12594953bf0ae8e09a673c66 |
| institution | OA Journals |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-6b78debf12594953bf0ae8e09a673c662025-08-20T02:10:38ZengBMCDiabetology & Metabolic Syndrome1758-59962025-06-0117111810.1186/s13098-025-01772-yHypomagnesemia: exploring its multifaceted health impacts and associations with blood pressure regulation and metabolic syndromeWenlong Wu0Ming Gong1Pan Liu2Huiying Yu3Xue Gao4Xin Zhao5Department of Cardiology, the Second Hospital of Dalian Medical UniversityDepartment of Cardiology, the Second Hospital of Dalian Medical UniversityLaboratory of Basic Medicine, General Hospital of Northern Theater CommandLaboratory of Basic Medicine, General Hospital of Northern Theater CommandDepartment of Cardiology, the Second Hospital of Dalian Medical UniversityDepartment of Cardiology, the Second Hospital of Dalian Medical UniversityAbstract This article provides a comprehensive and in-depth exploration of the multifaceted effects of Hypomagnesemia on human health, with a specific focus on its intricate associations with mechanisms regulating blood pressure and metabolic syndrome. Firstly, the fundamental concept of hypomagnesemia is elucidated, followed by a detailed analysis of its prevalence, risk factors, and Magnesium Deficiency Score. Furthermore, this article delves into the intricate relationship between hypomagnesemia and blood pressure regulation, encompassing its impact on endothelial function, vascular calcification, oxidative stress and inflammatory response, sympathetic nervous system activity as well as the renin–angiotensin–aldosterone system (RAAS). Additionally, it explores the correlation between hypomagnesemia and insulin resistance, metabolic syndrome along with other health issues. Notably noteworthy is that this paper also places special emphasis on exploring the potential role of hypomagnesemia in specific diseases such as renal hypertension and preeclampsia while providing novel insights for their prevention and treatment. Finally, this article summarizes the diverse effects of hypomagnesemia on health while anticipating future research directions. Future studies should further investigate the pathogenesis underlying hypomagnesemia while optimizing assessment methods for magnesium deficiency to develop targeted intervention strategies aimed at offering improved treatment options alongside preventive measures for patients.https://doi.org/10.1186/s13098-025-01772-yHypomagnesemiaHypertensionHealthMetabolic syndrome |
| spellingShingle | Wenlong Wu Ming Gong Pan Liu Huiying Yu Xue Gao Xin Zhao Hypomagnesemia: exploring its multifaceted health impacts and associations with blood pressure regulation and metabolic syndrome Diabetology & Metabolic Syndrome Hypomagnesemia Hypertension Health Metabolic syndrome |
| title | Hypomagnesemia: exploring its multifaceted health impacts and associations with blood pressure regulation and metabolic syndrome |
| title_full | Hypomagnesemia: exploring its multifaceted health impacts and associations with blood pressure regulation and metabolic syndrome |
| title_fullStr | Hypomagnesemia: exploring its multifaceted health impacts and associations with blood pressure regulation and metabolic syndrome |
| title_full_unstemmed | Hypomagnesemia: exploring its multifaceted health impacts and associations with blood pressure regulation and metabolic syndrome |
| title_short | Hypomagnesemia: exploring its multifaceted health impacts and associations with blood pressure regulation and metabolic syndrome |
| title_sort | hypomagnesemia exploring its multifaceted health impacts and associations with blood pressure regulation and metabolic syndrome |
| topic | Hypomagnesemia Hypertension Health Metabolic syndrome |
| url | https://doi.org/10.1186/s13098-025-01772-y |
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