Associations between body mass index, high-sensitivity C-reactive protein, and depressive symptoms: NHANES 2015-2016
ObjectiveStudies have shown associations between Body Mass Index (BMI), High-Sensitivity C-reactive protein (HSCRP), and depressive symptoms(DP). However, the complex relationship between them remains uncertain. The objective of this research is to examine the correlation between them in a substanti...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1506726/full |
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| author | Yan Zhang Fengya Zhen Yaxing Zhang Cuixia An |
| author_facet | Yan Zhang Fengya Zhen Yaxing Zhang Cuixia An |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | ObjectiveStudies have shown associations between Body Mass Index (BMI), High-Sensitivity C-reactive protein (HSCRP), and depressive symptoms(DP). However, the complex relationship between them remains uncertain. The objective of this research is to examine the correlation between them in a substantial sample that is representative of the national level.MethodsOur analysis was based on the 2015-2016National Health and Nutrition Examination Survey (NHANES).DP was measured by the Patient Health Questionnaire-9 (PHQ-9). Using multivariable logistic regression analysis and stratified analysis, we examined the relationship between BMI, HSCRP, and DP. We applied generalized additive models to explore the non-linear relationships among variables.ResultsThis study included a total of 4834 participants. The results revealed that BMI (P=0.002) and HSCRP (P=0.008) were risk factors for DP. The relationship between BMI and DP (P=0.035), BMI and HSCRP (P<0.001) were non-linear. The nonlinear association between HSCRP and DP (P=0.031), BMI and DP (P=9e-04) is significant in females when stratified by gender. No nonlinear association was found between BMI and DP (P =0.677) and between HSCRP and DP (P =0.439) in males. The results of the interaction test reveal a significant interaction between HSCRP and gender.ConclusionsResearch has found both BMI and HSCRP are risk factors for DP and the relationship between them was non-linear. The nonlinear associations between BMI and DP, as well as between HSCRP and DP, are gender-dependent. |
| format | Article |
| id | doaj-art-6b75522c325e443db560cbe373912650 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj-art-6b75522c325e443db560cbe3739126502025-01-20T12:29:50ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011510.3389/fpsyt.2024.15067261506726Associations between body mass index, high-sensitivity C-reactive protein, and depressive symptoms: NHANES 2015-2016Yan ZhangFengya ZhenYaxing ZhangCuixia AnObjectiveStudies have shown associations between Body Mass Index (BMI), High-Sensitivity C-reactive protein (HSCRP), and depressive symptoms(DP). However, the complex relationship between them remains uncertain. The objective of this research is to examine the correlation between them in a substantial sample that is representative of the national level.MethodsOur analysis was based on the 2015-2016National Health and Nutrition Examination Survey (NHANES).DP was measured by the Patient Health Questionnaire-9 (PHQ-9). Using multivariable logistic regression analysis and stratified analysis, we examined the relationship between BMI, HSCRP, and DP. We applied generalized additive models to explore the non-linear relationships among variables.ResultsThis study included a total of 4834 participants. The results revealed that BMI (P=0.002) and HSCRP (P=0.008) were risk factors for DP. The relationship between BMI and DP (P=0.035), BMI and HSCRP (P<0.001) were non-linear. The nonlinear association between HSCRP and DP (P=0.031), BMI and DP (P=9e-04) is significant in females when stratified by gender. No nonlinear association was found between BMI and DP (P =0.677) and between HSCRP and DP (P =0.439) in males. The results of the interaction test reveal a significant interaction between HSCRP and gender.ConclusionsResearch has found both BMI and HSCRP are risk factors for DP and the relationship between them was non-linear. The nonlinear associations between BMI and DP, as well as between HSCRP and DP, are gender-dependent.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1506726/fullBMIPHQ-9HSCRPDPinflammation |
| spellingShingle | Yan Zhang Fengya Zhen Yaxing Zhang Cuixia An Associations between body mass index, high-sensitivity C-reactive protein, and depressive symptoms: NHANES 2015-2016 Frontiers in Psychiatry BMI PHQ-9 HSCRP DP inflammation |
| title | Associations between body mass index, high-sensitivity C-reactive protein, and depressive symptoms: NHANES 2015-2016 |
| title_full | Associations between body mass index, high-sensitivity C-reactive protein, and depressive symptoms: NHANES 2015-2016 |
| title_fullStr | Associations between body mass index, high-sensitivity C-reactive protein, and depressive symptoms: NHANES 2015-2016 |
| title_full_unstemmed | Associations between body mass index, high-sensitivity C-reactive protein, and depressive symptoms: NHANES 2015-2016 |
| title_short | Associations between body mass index, high-sensitivity C-reactive protein, and depressive symptoms: NHANES 2015-2016 |
| title_sort | associations between body mass index high sensitivity c reactive protein and depressive symptoms nhanes 2015 2016 |
| topic | BMI PHQ-9 HSCRP DP inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1506726/full |
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