Apolipoprotein E allelic variants and cerebral palsy
Cerebral palsy (CP) is the most frequent cause of mobility restriction and posture disturbance in childhood. Against the complexity in disease etiology, genetic factors, including Apolipoprotein E allelic distribution in this patient population, are worthy targets for investigation. ApoE is a lipop...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2018-08-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/869 |
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| author | Evren Gümüş Beyhan Durak Aras Oğuz Çilingir Coşkun Yarar Kürşat Bora Çarman Sibel Laçiner-Gürlevik Ozan Koçak Sevilhan Artan |
| author_facet | Evren Gümüş Beyhan Durak Aras Oğuz Çilingir Coşkun Yarar Kürşat Bora Çarman Sibel Laçiner-Gürlevik Ozan Koçak Sevilhan Artan |
| author_sort | Evren Gümüş |
| collection | DOAJ |
| description |
Cerebral palsy (CP) is the most frequent cause of mobility restriction and posture disturbance in childhood. Against the complexity in disease etiology, genetic factors, including Apolipoprotein E allelic distribution in this patient population, are worthy targets for investigation. ApoE is a lipoprotein of central nervous system encoded by ApoE gene with its 3 main co-dominant alleles, 2, 3 and 4. We aimed to evaluate the allelic frequencies of ApoE gene and its association with coexisting clinical entities such as vision and hearing impairment, cognitive problems, seizures and MRI findings in a pediatric patient population native to middle Anatolian region. Seventy-eight children with CP and 60 healthy controls were genotyped. Genotypic variations along with coexisting clinical conditions and CP-related medical findings were compared between the patient and control groups. The Denver Developmental Screening Test for all, the Wechsler Intelligence Scale for Children-IV (short form WISC-IV; Turkish version) for the patients > 6y and the Stanford-Binet Intelligence Scale (SB-5) for those who aged 2-6 years old were employed to evaluate cognitive and mental abilities of the patients. ApoE 2 and 4 alleles were more frequent in the patient group (p < 0.05), whereas ApoE 3 allele was more frequent in the healthy controls. ApoE 2/4 genotype has been determined 29% in the case group, but none in healthy control group. In the patient group with apolipoprotein 4 or 2 alleles, the rate of emergency cesarean section was found being significantly higher than the group with 3 allele. Brain MRI findings were not significantly different among ApoE allelic variants within the patient group. Our data show that the ApoE alleles may be effective in the development of cerebral palsy and may be associated with some clinical manifestations in those patients.
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| format | Article |
| id | doaj-art-6b74877f4c484283b20b01df388ca3e7 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-6b74877f4c484283b20b01df388ca3e72025-08-20T02:55:41ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212018-08-0160410.24953/turkjped.2018.04.002Apolipoprotein E allelic variants and cerebral palsyEvren Gümüş0Beyhan Durak Aras1Oğuz Çilingir2Coşkun Yarar3Kürşat Bora Çarman4Sibel Laçiner-Gürlevik5Ozan Koçak6Sevilhan Artan7Departments of Medical Genetics Osmangazi University, Faculty of Medicine, Eskisehir, Turkey.Departments of Medical Genetics Osmangazi University, Faculty of Medicine, Eskisehir, Turkey.Departments of Medical Genetics Osmangazi University, Faculty of Medicine, Eskisehir, Turkey.Departments of Pediatrics, Osmangazi University, Faculty of Medicine, Eskisehir, Turkey.Departments of Pediatrics, Osmangazi University, Faculty of Medicine, Eskisehir, Turkey.Departments of Pediatrics, Osmangazi University, Faculty of Medicine, Eskisehir, Turkey.Departments of Pediatrics, Osmangazi University, Faculty of Medicine, Eskisehir, Turkey.Departments of Medical Genetics Osmangazi University, Faculty of Medicine, Eskisehir, Turkey. Cerebral palsy (CP) is the most frequent cause of mobility restriction and posture disturbance in childhood. Against the complexity in disease etiology, genetic factors, including Apolipoprotein E allelic distribution in this patient population, are worthy targets for investigation. ApoE is a lipoprotein of central nervous system encoded by ApoE gene with its 3 main co-dominant alleles, 2, 3 and 4. We aimed to evaluate the allelic frequencies of ApoE gene and its association with coexisting clinical entities such as vision and hearing impairment, cognitive problems, seizures and MRI findings in a pediatric patient population native to middle Anatolian region. Seventy-eight children with CP and 60 healthy controls were genotyped. Genotypic variations along with coexisting clinical conditions and CP-related medical findings were compared between the patient and control groups. The Denver Developmental Screening Test for all, the Wechsler Intelligence Scale for Children-IV (short form WISC-IV; Turkish version) for the patients > 6y and the Stanford-Binet Intelligence Scale (SB-5) for those who aged 2-6 years old were employed to evaluate cognitive and mental abilities of the patients. ApoE 2 and 4 alleles were more frequent in the patient group (p < 0.05), whereas ApoE 3 allele was more frequent in the healthy controls. ApoE 2/4 genotype has been determined 29% in the case group, but none in healthy control group. In the patient group with apolipoprotein 4 or 2 alleles, the rate of emergency cesarean section was found being significantly higher than the group with 3 allele. Brain MRI findings were not significantly different among ApoE allelic variants within the patient group. Our data show that the ApoE alleles may be effective in the development of cerebral palsy and may be associated with some clinical manifestations in those patients. https://turkjpediatr.org/article/view/869GMFCSapoEcerebral palsyneurodevelopment |
| spellingShingle | Evren Gümüş Beyhan Durak Aras Oğuz Çilingir Coşkun Yarar Kürşat Bora Çarman Sibel Laçiner-Gürlevik Ozan Koçak Sevilhan Artan Apolipoprotein E allelic variants and cerebral palsy The Turkish Journal of Pediatrics GMFCS apoE cerebral palsy neurodevelopment |
| title | Apolipoprotein E allelic variants and cerebral palsy |
| title_full | Apolipoprotein E allelic variants and cerebral palsy |
| title_fullStr | Apolipoprotein E allelic variants and cerebral palsy |
| title_full_unstemmed | Apolipoprotein E allelic variants and cerebral palsy |
| title_short | Apolipoprotein E allelic variants and cerebral palsy |
| title_sort | apolipoprotein e allelic variants and cerebral palsy |
| topic | GMFCS apoE cerebral palsy neurodevelopment |
| url | https://turkjpediatr.org/article/view/869 |
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