Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake
Addressing the consequences of exposure to endocrine-disrupting chemicals (EDCs) demands thorough research and elucidation of the mechanism by which EDCs negatively impact women and lead to breast cancer (BC). Endocrine disruptors can affect major pathways through various means, including histone mo...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2039-4713/15/1/1 |
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| author | Desh Deepak Singh |
| author_facet | Desh Deepak Singh |
| author_sort | Desh Deepak Singh |
| collection | DOAJ |
| description | Addressing the consequences of exposure to endocrine-disrupting chemicals (EDCs) demands thorough research and elucidation of the mechanism by which EDCs negatively impact women and lead to breast cancer (BC). Endocrine disruptors can affect major pathways through various means, including histone modifications, the erroneous expression of microRNA (miRNA), DNA methylation, and epigenetic modifications. However, it is still uncertain if the epigenetic modifications triggered by EDCs can help predict negative outcomes. Consequently, it is important to understand how different endocrine disrupters or signals interact with epigenetic modifications and regulate signalling mechanisms. This study proposes that the epigenome may be negatively impacted by several EDCs, such as cadmium, arsenic, lead, bisphenol A, phthalates, polychlorinated biphenyls and parabens, organochlorine, and dioxins. Further, this study also examines the impact of EDCs on lifestyle variables. In breast cancer research, it is essential to consider the potential impacts of EDC exposure and comprehend how EDCs function in tissues. |
| format | Article |
| id | doaj-art-6b73cbb0d83e433aa1a0b559df774eae |
| institution | DOAJ |
| issn | 2039-4705 2039-4713 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Xenobiotics |
| spelling | doaj-art-6b73cbb0d83e433aa1a0b559df774eae2025-08-20T03:12:15ZengMDPI AGJournal of Xenobiotics2039-47052039-47132024-12-01151110.3390/jox15010001Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary IntakeDesh Deepak Singh0Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, IndiaAddressing the consequences of exposure to endocrine-disrupting chemicals (EDCs) demands thorough research and elucidation of the mechanism by which EDCs negatively impact women and lead to breast cancer (BC). Endocrine disruptors can affect major pathways through various means, including histone modifications, the erroneous expression of microRNA (miRNA), DNA methylation, and epigenetic modifications. However, it is still uncertain if the epigenetic modifications triggered by EDCs can help predict negative outcomes. Consequently, it is important to understand how different endocrine disrupters or signals interact with epigenetic modifications and regulate signalling mechanisms. This study proposes that the epigenome may be negatively impacted by several EDCs, such as cadmium, arsenic, lead, bisphenol A, phthalates, polychlorinated biphenyls and parabens, organochlorine, and dioxins. Further, this study also examines the impact of EDCs on lifestyle variables. In breast cancer research, it is essential to consider the potential impacts of EDC exposure and comprehend how EDCs function in tissues.https://www.mdpi.com/2039-4713/15/1/1endocrine disruptorsepigeneticbreast cancerdietary exposure |
| spellingShingle | Desh Deepak Singh Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake Journal of Xenobiotics endocrine disruptors epigenetic breast cancer dietary exposure |
| title | Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake |
| title_full | Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake |
| title_fullStr | Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake |
| title_full_unstemmed | Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake |
| title_short | Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake |
| title_sort | epigenetic mechanisms of endocrine disrupting chemicals in breast cancer and their impact on dietary intake |
| topic | endocrine disruptors epigenetic breast cancer dietary exposure |
| url | https://www.mdpi.com/2039-4713/15/1/1 |
| work_keys_str_mv | AT deshdeepaksingh epigeneticmechanismsofendocrinedisruptingchemicalsinbreastcancerandtheirimpactondietaryintake |