Plasma extracellular vesicle surface-located GAS6/PROS1 and CD39/CD73 attenuate inflammation

Plasma extracellular vesicle surface-located GAS6/PROS1 and CD39/CD73 attenuate inflammation

Summary: Herein, we demonstrate that extracellular vesicles (EVs) present in healthy human plasma regulate macrophage activation by triggering MERTK-dependent signaling in a growth arrest-specific 6 (GAS6)- and protein S (PROS1)-dependent manner. Moreover, EVs regulate oxidative burst and degranulat...

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Main Authors: Martina P. Fabiano, Alan M. Adamczyk, Olesia A. Gololobova, Ignacio G. Mazzitelli, María L. Leicaj, Tomás M. Grosso, Paula S. Pérez, Cora L. Alvarez, Julieta Schachter, Silvina Palmer, Florencia Sabbione, Fernando A. Erra Díaz, Analía S. Trevani, Manuel Varas-Godoy, Eugenio A. Carrera Silva, Kenneth W. Witwer, Matías Ostrowski
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008678
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