Formulation and in-vitro antioxidant evaluation of α-mangostin, piperin, curcumin in oral patch and their combination
Natural antioxidants have been developed in various formulations as alternatives to reduce the side effects associated with synthetic antioxidants. α-Mangostin exhibits strong antioxidant properties, although its behavior in combination with other herbal compounds remains unclear. The aim of this st...
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| Format: | Article |
| Language: | English |
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Universitas Ahmad Dahlan
2025-07-01
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| Series: | Pharmaciana |
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| Online Access: | https://journal.uad.ac.id/index.php/PHARMACIANA/article/view/29906 |
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| author | Ine Suharyani Suharyani Richa Mardianingrum Yuniarti Falya Rizki Pratama Ibnu Mas'ud Isti Daruwati |
| author_facet | Ine Suharyani Suharyani Richa Mardianingrum Yuniarti Falya Rizki Pratama Ibnu Mas'ud Isti Daruwati |
| author_sort | Ine Suharyani Suharyani |
| collection | DOAJ |
| description | Natural antioxidants have been developed in various formulations as alternatives to reduce the side effects associated with synthetic antioxidants. α-Mangostin exhibits strong antioxidant properties, although its behavior in combination with other herbal compounds remains unclear. The aim of this study was to formulate a combination of α-M, piperine, and curcumin into an oral patch and to evaluate the antioxidant properties of α-M when combined with piperine and curcumin, both known natural antioxidants. The oral patches were prepared by incorporating the active compounds (α-mangostin, piperine, and curcumin) into a matrix of hydroxypropyl methylcellulose (HPMC), gelatin, and chitosan. Glycerin was added as a plasticizer. Organoleptic assessment, along with evaluations of pH, weight, folding endurance, and moisture absorption capacity, confirmed the successful formulation of α-mangostin (MP), piperine (PP), curcumin (CP), and combination (MPCP) patches as oral delivery systems. All patches maintained a pH above 5.5. The thicknesses of MP, PP, CP, and MPCP were measured at 0.14 ± 0.02 mm, 0.17 ± 0.01 mm, 0.15 ± 0.02 mm, 0.11 ± 0.01 mm, and 0.16 ± 0.02 mm, respectively. The combination of these natural compounds enhanced folding endurance compared to the individual curcumin and piperine patches, while slightly reducing antioxidant activity. The co-formulation of α-mangostin, piperine, and curcumin into a single oral patch demonstrated a modest decline in antioxidant capacity. This study aimed to assess the impact of combining multiple antioxidant-rich natural compounds within a single delivery system. |
| format | Article |
| id | doaj-art-6b69ec8aacb540219d15ce42e95ea7ef |
| institution | Kabale University |
| issn | 2088-4559 2477-0256 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Universitas Ahmad Dahlan |
| record_format | Article |
| series | Pharmaciana |
| spelling | doaj-art-6b69ec8aacb540219d15ce42e95ea7ef2025-08-20T03:44:40ZengUniversitas Ahmad DahlanPharmaciana2088-45592477-02562025-07-0115224025110.12928/pharmaciana.v15i2.2990621457Formulation and in-vitro antioxidant evaluation of α-mangostin, piperin, curcumin in oral patch and their combinationIne Suharyani Suharyani0Richa Mardianingrum1Yuniarti Falya2Rizki Pratama3Ibnu Mas'ud4Isti Daruwati5Universitas Muhammadiyah Ahmad Dahlan CirebonUniversitas Perjuangan TasikmalayaUniversitas Muhammadiyah Ahmad Dahlan CirebonUniversitas Muhammadiyah Ahmad Dahlan CirebonUniversitas Muhammadiyah Ahmad Dahlan CirebonNational Research and Innovation Agency (BRIN)Natural antioxidants have been developed in various formulations as alternatives to reduce the side effects associated with synthetic antioxidants. α-Mangostin exhibits strong antioxidant properties, although its behavior in combination with other herbal compounds remains unclear. The aim of this study was to formulate a combination of α-M, piperine, and curcumin into an oral patch and to evaluate the antioxidant properties of α-M when combined with piperine and curcumin, both known natural antioxidants. The oral patches were prepared by incorporating the active compounds (α-mangostin, piperine, and curcumin) into a matrix of hydroxypropyl methylcellulose (HPMC), gelatin, and chitosan. Glycerin was added as a plasticizer. Organoleptic assessment, along with evaluations of pH, weight, folding endurance, and moisture absorption capacity, confirmed the successful formulation of α-mangostin (MP), piperine (PP), curcumin (CP), and combination (MPCP) patches as oral delivery systems. All patches maintained a pH above 5.5. The thicknesses of MP, PP, CP, and MPCP were measured at 0.14 ± 0.02 mm, 0.17 ± 0.01 mm, 0.15 ± 0.02 mm, 0.11 ± 0.01 mm, and 0.16 ± 0.02 mm, respectively. The combination of these natural compounds enhanced folding endurance compared to the individual curcumin and piperine patches, while slightly reducing antioxidant activity. The co-formulation of α-mangostin, piperine, and curcumin into a single oral patch demonstrated a modest decline in antioxidant capacity. This study aimed to assess the impact of combining multiple antioxidant-rich natural compounds within a single delivery system.https://journal.uad.ac.id/index.php/PHARMACIANA/article/view/29906patch, α-mangostin, ppiperin, curcumin, antioxidant, |
| spellingShingle | Ine Suharyani Suharyani Richa Mardianingrum Yuniarti Falya Rizki Pratama Ibnu Mas'ud Isti Daruwati Formulation and in-vitro antioxidant evaluation of α-mangostin, piperin, curcumin in oral patch and their combination Pharmaciana patch, α-mangostin, ppiperin, curcumin, antioxidant, |
| title | Formulation and in-vitro antioxidant evaluation of α-mangostin, piperin, curcumin in oral patch and their combination |
| title_full | Formulation and in-vitro antioxidant evaluation of α-mangostin, piperin, curcumin in oral patch and their combination |
| title_fullStr | Formulation and in-vitro antioxidant evaluation of α-mangostin, piperin, curcumin in oral patch and their combination |
| title_full_unstemmed | Formulation and in-vitro antioxidant evaluation of α-mangostin, piperin, curcumin in oral patch and their combination |
| title_short | Formulation and in-vitro antioxidant evaluation of α-mangostin, piperin, curcumin in oral patch and their combination |
| title_sort | formulation and in vitro antioxidant evaluation of α mangostin piperin curcumin in oral patch and their combination |
| topic | patch, α-mangostin, ppiperin, curcumin, antioxidant, |
| url | https://journal.uad.ac.id/index.php/PHARMACIANA/article/view/29906 |
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