Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation
The emergence of single-cell genomic and transcriptomic sequencing accelerates the development of single-cell epigenomic technologies, providing an unprecedented opportunity for decoding cell fate decisions largely encoded in the epigenome. Recent advances in single-cell multimodality epigenomic tec...
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| Format: | Article |
| Language: | English |
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Science Press
2023-03-01
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| Series: | National Science Open |
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| Online Access: | https://www.sciengine.com/doi/10.1360/nso/20220057 |
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| author | Xiong Haiqing Wang Runyu He Aibin |
| author_facet | Xiong Haiqing Wang Runyu He Aibin |
| author_sort | Xiong Haiqing |
| collection | DOAJ |
| description | The emergence of single-cell genomic and transcriptomic sequencing accelerates the development of single-cell epigenomic technologies, providing an unprecedented opportunity for decoding cell fate decisions largely encoded in the epigenome. Recent advances in single-cell multimodality epigenomic technologies facilitate directly interrogating the regulatory relationship between multi-layer molecular information in the same cell. In this review, we discuss recent progress in development of single-cell multimodality epigenomic technologies and applications in elucidating cellular diversifications in development and diseases, with a focus on protein-DNA interactomics and regulatory links between epigenome and transcriptome. Further, we provide perspective on the future direction of single-cell multiomics tool development as well as challenges facing ahead. |
| format | Article |
| id | doaj-art-6b6877c7271644aabb37cd90aa4fa76f |
| institution | DOAJ |
| issn | 2097-1168 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Science Press |
| record_format | Article |
| series | National Science Open |
| spelling | doaj-art-6b6877c7271644aabb37cd90aa4fa76f2025-08-20T02:47:08ZengScience PressNational Science Open2097-11682023-03-01210.1360/nso/20220057eb33e642Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulationXiong Haiqing0Wang Runyu1He Aibin2["State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China"]["Peking University-Tsinghua University-National Institute of Biological Science Joint Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China"]["Institute of Molecular Medicine, College of Future Technology, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China"]The emergence of single-cell genomic and transcriptomic sequencing accelerates the development of single-cell epigenomic technologies, providing an unprecedented opportunity for decoding cell fate decisions largely encoded in the epigenome. Recent advances in single-cell multimodality epigenomic technologies facilitate directly interrogating the regulatory relationship between multi-layer molecular information in the same cell. In this review, we discuss recent progress in development of single-cell multimodality epigenomic technologies and applications in elucidating cellular diversifications in development and diseases, with a focus on protein-DNA interactomics and regulatory links between epigenome and transcriptome. Further, we provide perspective on the future direction of single-cell multiomics tool development as well as challenges facing ahead.https://www.sciengine.com/doi/10.1360/nso/20220057single-cell protein-DNA interactionsingle-cell multiomicssingle-cell epigenomicsepigenomegenome regulation |
| spellingShingle | Xiong Haiqing Wang Runyu He Aibin Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation National Science Open single-cell protein-DNA interaction single-cell multiomics single-cell epigenomics epigenome genome regulation |
| title | Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation |
| title_full | Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation |
| title_fullStr | Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation |
| title_full_unstemmed | Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation |
| title_short | Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation |
| title_sort | single cell protein dna interactomics and multiomics tools for deciphering genome regulation |
| topic | single-cell protein-DNA interaction single-cell multiomics single-cell epigenomics epigenome genome regulation |
| url | https://www.sciengine.com/doi/10.1360/nso/20220057 |
| work_keys_str_mv | AT xionghaiqing singlecellproteindnainteractomicsandmultiomicstoolsfordecipheringgenomeregulation AT wangrunyu singlecellproteindnainteractomicsandmultiomicstoolsfordecipheringgenomeregulation AT heaibin singlecellproteindnainteractomicsandmultiomicstoolsfordecipheringgenomeregulation |