Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation
The emergence of single-cell genomic and transcriptomic sequencing accelerates the development of single-cell epigenomic technologies, providing an unprecedented opportunity for decoding cell fate decisions largely encoded in the epigenome. Recent advances in single-cell multimodality epigenomic tec...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Science Press
2023-03-01
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| Series: | National Science Open |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.1360/nso/20220057 |
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| Summary: | The emergence of single-cell genomic and transcriptomic sequencing accelerates the development of single-cell epigenomic technologies, providing an unprecedented opportunity for decoding cell fate decisions largely encoded in the epigenome. Recent advances in single-cell multimodality epigenomic technologies facilitate directly interrogating the regulatory relationship between multi-layer molecular information in the same cell. In this review, we discuss recent progress in development of single-cell multimodality epigenomic technologies and applications in elucidating cellular diversifications in development and diseases, with a focus on protein-DNA interactomics and regulatory links between epigenome and transcriptome. Further, we provide perspective on the future direction of single-cell multiomics tool development as well as challenges facing ahead. |
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| ISSN: | 2097-1168 |