Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulfate Gargling for the Prevention of Postoperative Sore Throat after Tracheal Intubation: A Randomized, Double-Blind, Non-Inferiority Trial
Linxin Wang, Yuqing Liu, Fangfang Li, Qin Qiu, Xingyu Xiong, Guanglei Wang Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Guanglei Wang, Department of Anesthesiology, The Affiliated Hospital of Xuzhou Med...
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Dove Medical Press
2025-03-01
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| author | Wang L Liu Y Li F Qiu Q Xiong X Wang G |
| author_facet | Wang L Liu Y Li F Qiu Q Xiong X Wang G |
| author_sort | Wang L |
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| description | Linxin Wang, Yuqing Liu, Fangfang Li, Qin Qiu, Xingyu Xiong, Guanglei Wang Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Guanglei Wang, Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, 99 huaihai Road West, Quanshan District, Xuzhou, Jiangsu, 221006, People’s Republic of China, Tel +86 13852087156, Email 13852087156@163.comBackground and Aim: Postoperative sore throat is a common complication following endotracheal intubation, which can significantly affect patient comfort and recovery. The purpose of this study is that compares the efficacy of preoperative topical magnesium sulfate spraying with that of magnesium sulfate gargling aimed at preventing postoperative sore throat.Patients and Methods: 236 Participants were randomly allocated to either the magnesium sulfate spray group (Group A) or the magnesium sulfate gargle group (Group B), with 118 patients in each group. In Group A, during intubation under direct laryngoscopy, 15 mg/kg of magnesium sulfate was sprayed using a single-use otorhinolaryngology anesthesia sprayer onto the pharyngeal mucosa and posterior pharyngeal wall near the glottis. In Group B, gargling with 20 mg/kg of magnesium sulfate for 30 seconds 15 minutes before surgery. The primary outcome measure was the total incidence of postoperative sore throat within 48 hours, with a non-inferiority margin of 0.15.Results: The upper limit of the 95% confidence interval (CI) for the difference in the total incidence of POST between Group A and Group B was below the non-inferiority margin (0.15) (non-inferiority P< 0.001). The upper limits of the 95% CI for the differences in the incidence rates of POST between Group A and Group B at time points T1- T6 were all below the non-inferiority margin (all non-inferiority P< 0.001). The total incidence of POST (P=0.046) and the incidence of POST at T2-T4 (all P< 0.001) in group A were lower than those in group B. The analysis of the individual effects between groups indicated significant differences in POST NRS scores at T1 (P=0.034) and T2-T4 (all P< 0.001).Conclusion: The local spray of magnesium sulfate on the throat before surgery to prevent postoperative sore throat is not inferior to, and may even be superior to, gargling with magnesium sulfate.Keywords: postoperative sore throat, magnesium sulfate, endotracheal intubation, general anaesthesia |
| format | Article |
| id | doaj-art-6b5ade4f6fd74d779bae8ce087a8c9d1 |
| institution | DOAJ |
| issn | 1177-8881 |
| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-6b5ade4f6fd74d779bae8ce087a8c9d12025-08-20T02:57:25ZengDove Medical PressDrug Design, Development and Therapy1177-88812025-03-01Volume 1917411752100998Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulfate Gargling for the Prevention of Postoperative Sore Throat after Tracheal Intubation: A Randomized, Double-Blind, Non-Inferiority TrialWang LLiu YLi FQiu QXiong XWang GLinxin Wang, Yuqing Liu, Fangfang Li, Qin Qiu, Xingyu Xiong, Guanglei Wang Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Guanglei Wang, Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, 99 huaihai Road West, Quanshan District, Xuzhou, Jiangsu, 221006, People’s Republic of China, Tel +86 13852087156, Email 13852087156@163.comBackground and Aim: Postoperative sore throat is a common complication following endotracheal intubation, which can significantly affect patient comfort and recovery. The purpose of this study is that compares the efficacy of preoperative topical magnesium sulfate spraying with that of magnesium sulfate gargling aimed at preventing postoperative sore throat.Patients and Methods: 236 Participants were randomly allocated to either the magnesium sulfate spray group (Group A) or the magnesium sulfate gargle group (Group B), with 118 patients in each group. In Group A, during intubation under direct laryngoscopy, 15 mg/kg of magnesium sulfate was sprayed using a single-use otorhinolaryngology anesthesia sprayer onto the pharyngeal mucosa and posterior pharyngeal wall near the glottis. In Group B, gargling with 20 mg/kg of magnesium sulfate for 30 seconds 15 minutes before surgery. The primary outcome measure was the total incidence of postoperative sore throat within 48 hours, with a non-inferiority margin of 0.15.Results: The upper limit of the 95% confidence interval (CI) for the difference in the total incidence of POST between Group A and Group B was below the non-inferiority margin (0.15) (non-inferiority P< 0.001). The upper limits of the 95% CI for the differences in the incidence rates of POST between Group A and Group B at time points T1- T6 were all below the non-inferiority margin (all non-inferiority P< 0.001). The total incidence of POST (P=0.046) and the incidence of POST at T2-T4 (all P< 0.001) in group A were lower than those in group B. The analysis of the individual effects between groups indicated significant differences in POST NRS scores at T1 (P=0.034) and T2-T4 (all P< 0.001).Conclusion: The local spray of magnesium sulfate on the throat before surgery to prevent postoperative sore throat is not inferior to, and may even be superior to, gargling with magnesium sulfate.Keywords: postoperative sore throat, magnesium sulfate, endotracheal intubation, general anaesthesiahttps://www.dovepress.com/comparison-of-preoperative-topical-magnesium-sulfate-spraying-and-magn-peer-reviewed-fulltext-article-DDDTpostoperative sore throatmagnesium sulfateendotracheal intubationgeneral anaesthesia |
| spellingShingle | Wang L Liu Y Li F Qiu Q Xiong X Wang G Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulfate Gargling for the Prevention of Postoperative Sore Throat after Tracheal Intubation: A Randomized, Double-Blind, Non-Inferiority Trial Drug Design, Development and Therapy postoperative sore throat magnesium sulfate endotracheal intubation general anaesthesia |
| title | Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulfate Gargling for the Prevention of Postoperative Sore Throat after Tracheal Intubation: A Randomized, Double-Blind, Non-Inferiority Trial |
| title_full | Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulfate Gargling for the Prevention of Postoperative Sore Throat after Tracheal Intubation: A Randomized, Double-Blind, Non-Inferiority Trial |
| title_fullStr | Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulfate Gargling for the Prevention of Postoperative Sore Throat after Tracheal Intubation: A Randomized, Double-Blind, Non-Inferiority Trial |
| title_full_unstemmed | Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulfate Gargling for the Prevention of Postoperative Sore Throat after Tracheal Intubation: A Randomized, Double-Blind, Non-Inferiority Trial |
| title_short | Comparison of Preoperative Topical Magnesium Sulfate Spraying and Magnesium Sulfate Gargling for the Prevention of Postoperative Sore Throat after Tracheal Intubation: A Randomized, Double-Blind, Non-Inferiority Trial |
| title_sort | comparison of preoperative topical magnesium sulfate spraying and magnesium sulfate gargling for the prevention of postoperative sore throat after tracheal intubation a randomized double blind non inferiority trial |
| topic | postoperative sore throat magnesium sulfate endotracheal intubation general anaesthesia |
| url | https://www.dovepress.com/comparison-of-preoperative-topical-magnesium-sulfate-spraying-and-magn-peer-reviewed-fulltext-article-DDDT |
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