The Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in Liver Cirrhosis Patient
Introduction: The psychometric hepatic encephalopathy score (PHES) is a tool that can be considered as a gold standard for detecting minimal hepatic encephalopathy (MHE) in liver cirrhosis patients. The PHES must be standardized based on the local healthy population before it can be used. The purpos...
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Interna Publishing
2024-05-01
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| Series: | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
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| Online Access: | https://ina-jghe.com/index.php/jghe/article/view/961 |
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| author | Cokorde Istri Yuliandari Krisnawardani Kumbara I Dewa Nyoman Wibawa I Gde Raka Widiana |
| author_facet | Cokorde Istri Yuliandari Krisnawardani Kumbara I Dewa Nyoman Wibawa I Gde Raka Widiana |
| author_sort | Cokorde Istri Yuliandari Krisnawardani Kumbara |
| collection | DOAJ |
| description | Introduction: The psychometric hepatic encephalopathy score (PHES) is a tool that can be considered as a gold standard for detecting minimal hepatic encephalopathy (MHE) in liver cirrhosis patients. The PHES must be standardized based on the local healthy population before it can be used. The purpose of this study is to standardize the PHES with Indonesian local populations and set the cutoff point of PHES so it can be used to detect MHE in liver cirrhosis patients.
Methods: PHES were administered to all enrolled subjects, which are healthy subjects and cirrhosis without overt encephalopathy subjects. The PHES consists of 5 psychometric tests. The influencing factors of PHES were assessed, and equations were developed to predict the expected result of each test. Diagnosis of MHE was built upon the deviation from the normal range value of PHES.
Results: In total, 236 subjects participated in this research. The influencing factors of PHES of this study were age and education years. With the cutoff point of PHES less than -4, the prevalence of MHE was 37.7%, of which 7.6%, 50%, and 50% had Child-Turcotte-Pugh (CTP) grade A, B, and C respectively.
Conclusions: The standardized version of PHES can be used to diagnose MHE in Indonesian liver cirrhosis patients. The PHES in this study were affected by age and education years. MHE was diagnosed if the PHES was less than -4. The incidence of MHE was found to increase along with the increase of the liver disease severity |
| format | Article |
| id | doaj-art-6b597d0f91bc4fc399e691a9e1c1ce39 |
| institution | Kabale University |
| issn | 1411-4801 2302-8181 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
| spelling | doaj-art-6b597d0f91bc4fc399e691a9e1c1ce392025-08-20T03:53:56ZengInterna PublishingThe Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy1411-48012302-81812024-05-01251404610.24871/251202440-46864The Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in Liver Cirrhosis PatientCokorde Istri Yuliandari Krisnawardani Kumbara0I Dewa Nyoman Wibawa1I Gde Raka Widiana2Department of Internal Medicine, Faculty of Medicine of Udayana University, Udayana University Hospital, Badung, Bali, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine Udayana University, Denpasar, Bali, IndonesiaDivision of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Udayana University, Denpasar, Bali, IndonesiaIntroduction: The psychometric hepatic encephalopathy score (PHES) is a tool that can be considered as a gold standard for detecting minimal hepatic encephalopathy (MHE) in liver cirrhosis patients. The PHES must be standardized based on the local healthy population before it can be used. The purpose of this study is to standardize the PHES with Indonesian local populations and set the cutoff point of PHES so it can be used to detect MHE in liver cirrhosis patients. Methods: PHES were administered to all enrolled subjects, which are healthy subjects and cirrhosis without overt encephalopathy subjects. The PHES consists of 5 psychometric tests. The influencing factors of PHES were assessed, and equations were developed to predict the expected result of each test. Diagnosis of MHE was built upon the deviation from the normal range value of PHES. Results: In total, 236 subjects participated in this research. The influencing factors of PHES of this study were age and education years. With the cutoff point of PHES less than -4, the prevalence of MHE was 37.7%, of which 7.6%, 50%, and 50% had Child-Turcotte-Pugh (CTP) grade A, B, and C respectively. Conclusions: The standardized version of PHES can be used to diagnose MHE in Indonesian liver cirrhosis patients. The PHES in this study were affected by age and education years. MHE was diagnosed if the PHES was less than -4. The incidence of MHE was found to increase along with the increase of the liver disease severityhttps://ina-jghe.com/index.php/jghe/article/view/961minimal hepatic encephalopathyliver cirrhosispsychometric hepatic encephalopathy score |
| spellingShingle | Cokorde Istri Yuliandari Krisnawardani Kumbara I Dewa Nyoman Wibawa I Gde Raka Widiana The Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in Liver Cirrhosis Patient The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy minimal hepatic encephalopathy liver cirrhosis psychometric hepatic encephalopathy score |
| title | The Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in Liver Cirrhosis Patient |
| title_full | The Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in Liver Cirrhosis Patient |
| title_fullStr | The Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in Liver Cirrhosis Patient |
| title_full_unstemmed | The Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in Liver Cirrhosis Patient |
| title_short | The Psychometric Hepatic Encephalopathy Score for Diagnosis of Minimal Hepatic Encephalopathy in Liver Cirrhosis Patient |
| title_sort | psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in liver cirrhosis patient |
| topic | minimal hepatic encephalopathy liver cirrhosis psychometric hepatic encephalopathy score |
| url | https://ina-jghe.com/index.php/jghe/article/view/961 |
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