Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study
Background. The aim of this study was thus to evaluate the feasibility and safety of taking biopsy specimens by cryoprobe from the parietal pleura during semirigid pleuroscope. Methods. In a single-center, observational, prospective study, patients with exudative pleural effusion (EPE) were evaluate...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2018/6746470 |
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| author | Chia-Hung Chen Wen-Chien Cheng Biing-Ru Wu Chih-Yu Chen Wei-Chun Chen Wei-Chih Liao Chih-Yen Tu |
| author_facet | Chia-Hung Chen Wen-Chien Cheng Biing-Ru Wu Chih-Yu Chen Wei-Chun Chen Wei-Chih Liao Chih-Yen Tu |
| author_sort | Chia-Hung Chen |
| collection | DOAJ |
| description | Background. The aim of this study was thus to evaluate the feasibility and safety of taking biopsy specimens by cryoprobe from the parietal pleura during semirigid pleuroscope. Methods. In a single-center, observational, prospective study, patients with exudative pleural effusion (EPE) were evaluated with a semirigid pleuroscope between January 2015 and July 2017. Each patient underwent pleural biopsy using flexible forceps and flexible cryoprobe through pleuroscope following diagnostic thoracentesis and closed pleural biopsy (CPB). Results. A total of 92 patients (median age 64 years) were included in the study, most of whom were men (65.2%). Cytological cell block (CCB) and CPB made definitive diagnoses in 32/92 (34.8%) and 25/92 (27.5%), respectively; flexible forceps biopsy (FFB) and cryoprobe biopsy (CB) established definitive diagnoses in 84/92 (91.3%) and 91/92 (98.9%), respectively. The sample obtained by CB (9.4 ± 4.9 mm) was significantly larger than the other two methods: FFB (4.2 ± 2.3 mm) or CPB (1.9 ± 1.0 mm) (P<0.0001). The immunohistochemical (IHC) staining was more easily performed with CB (98.9%) compared to either FFB (87.0%) or CPB (13.0%). There were no significant complications or procedure-related deaths. Conclusions. Based on these results, CB during semirigid pleuroscope has a high diagnostic yield, differentiating EPE of unknown etiology with satisfactory effectiveness and safety. |
| format | Article |
| id | doaj-art-6b552ba54915430ba4b80e93069ce002 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-6b552ba54915430ba4b80e93069ce0022025-02-03T06:05:38ZengWileyCanadian Respiratory Journal1198-22411916-72452018-01-01201810.1155/2018/67464706746470Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective StudyChia-Hung Chen0Wen-Chien Cheng1Biing-Ru Wu2Chih-Yu Chen3Wei-Chun Chen4Wei-Chih Liao5Chih-Yen Tu6Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, TaiwanBackground. The aim of this study was thus to evaluate the feasibility and safety of taking biopsy specimens by cryoprobe from the parietal pleura during semirigid pleuroscope. Methods. In a single-center, observational, prospective study, patients with exudative pleural effusion (EPE) were evaluated with a semirigid pleuroscope between January 2015 and July 2017. Each patient underwent pleural biopsy using flexible forceps and flexible cryoprobe through pleuroscope following diagnostic thoracentesis and closed pleural biopsy (CPB). Results. A total of 92 patients (median age 64 years) were included in the study, most of whom were men (65.2%). Cytological cell block (CCB) and CPB made definitive diagnoses in 32/92 (34.8%) and 25/92 (27.5%), respectively; flexible forceps biopsy (FFB) and cryoprobe biopsy (CB) established definitive diagnoses in 84/92 (91.3%) and 91/92 (98.9%), respectively. The sample obtained by CB (9.4 ± 4.9 mm) was significantly larger than the other two methods: FFB (4.2 ± 2.3 mm) or CPB (1.9 ± 1.0 mm) (P<0.0001). The immunohistochemical (IHC) staining was more easily performed with CB (98.9%) compared to either FFB (87.0%) or CPB (13.0%). There were no significant complications or procedure-related deaths. Conclusions. Based on these results, CB during semirigid pleuroscope has a high diagnostic yield, differentiating EPE of unknown etiology with satisfactory effectiveness and safety.http://dx.doi.org/10.1155/2018/6746470 |
| spellingShingle | Chia-Hung Chen Wen-Chien Cheng Biing-Ru Wu Chih-Yu Chen Wei-Chun Chen Wei-Chih Liao Chih-Yen Tu Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study Canadian Respiratory Journal |
| title | Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study |
| title_full | Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study |
| title_fullStr | Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study |
| title_full_unstemmed | Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study |
| title_short | Feasibility and Safety of Pleuroscopic Cryobiopsy of the Pleura: A Prospective Study |
| title_sort | feasibility and safety of pleuroscopic cryobiopsy of the pleura a prospective study |
| url | http://dx.doi.org/10.1155/2018/6746470 |
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