Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives
As a typical pathological feature of pancreatic ductal adenocarcinoma, reprogramming of glucose metabolism synergistically drives the tumorigenesis and development process through molecular mechanisms such as regulating the expression of driver genes, modifying key functional proteins, triggering mi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586959/full |
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| _version_ | 1849473088617447424 |
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| author | Yan Zhang Wancheng Li Jubao Niu Zeyang Fan Xin Li Xin Li Hui Zhang Hui Zhang |
| author_facet | Yan Zhang Wancheng Li Jubao Niu Zeyang Fan Xin Li Xin Li Hui Zhang Hui Zhang |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | As a typical pathological feature of pancreatic ductal adenocarcinoma, reprogramming of glucose metabolism synergistically drives the tumorigenesis and development process through molecular mechanisms such as regulating the expression of driver genes, modifying key functional proteins, triggering mitochondrial metabolism abnormality, and remodeling the tumor microenvironment. It is worth noting that this metabolic remodeling phenomenon is significantly associated with the formation of chemoresistance. Based on the latest research progress, this paper systematically describes the molecular basis of glucose metabolic reprogramming in pancreatic cancer, drug resistance characteristics and its targeted intervention strategies, and provides a theoretical framework for the research and development of innovative drugs. |
| format | Article |
| id | doaj-art-6b537221f13846c7af3ffe9ea13b0ecc |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-6b537221f13846c7af3ffe9ea13b0ecc2025-08-20T03:24:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.15869591586959Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectivesYan Zhang0Wancheng Li1Jubao Niu2Zeyang Fan3Xin Li4Xin Li5Hui Zhang6Hui Zhang7The Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, The Second Hospital of Lanzhou University, The Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, The Second Hospital of Lanzhou University, The Second Clinical Medical School, Lanzhou University, Lanzhou, ChinaAs a typical pathological feature of pancreatic ductal adenocarcinoma, reprogramming of glucose metabolism synergistically drives the tumorigenesis and development process through molecular mechanisms such as regulating the expression of driver genes, modifying key functional proteins, triggering mitochondrial metabolism abnormality, and remodeling the tumor microenvironment. It is worth noting that this metabolic remodeling phenomenon is significantly associated with the formation of chemoresistance. Based on the latest research progress, this paper systematically describes the molecular basis of glucose metabolic reprogramming in pancreatic cancer, drug resistance characteristics and its targeted intervention strategies, and provides a theoretical framework for the research and development of innovative drugs.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586959/fullpancreatic cancerglucose metabolismtumor microenvironmenttreatment resistancetherapeutic strategy |
| spellingShingle | Yan Zhang Wancheng Li Jubao Niu Zeyang Fan Xin Li Xin Li Hui Zhang Hui Zhang Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives Frontiers in Immunology pancreatic cancer glucose metabolism tumor microenvironment treatment resistance therapeutic strategy |
| title | Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives |
| title_full | Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives |
| title_fullStr | Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives |
| title_full_unstemmed | Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives |
| title_short | Reprogramming of glucose metabolism in pancreatic cancer: mechanisms, implications, and therapeutic perspectives |
| title_sort | reprogramming of glucose metabolism in pancreatic cancer mechanisms implications and therapeutic perspectives |
| topic | pancreatic cancer glucose metabolism tumor microenvironment treatment resistance therapeutic strategy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586959/full |
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