Retrospective Analysis of High-Dose Intrathecal Morphine for Analgesia after Pelvic Surgery
BACKGROUND: The effectiveness of intrathecal opioids (ITOs) for postoperative analgesia has been limited by reduced opioid dosing because of opioid-related side effects, most importantly respiratory depression. To overcome these limitations, high-dose intrathecal morphine was combined with a continu...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2011/691712 |
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| _version_ | 1850158056379252736 |
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| author | Annette Rebel Paul Sloan Michael Andrykowski |
| author_facet | Annette Rebel Paul Sloan Michael Andrykowski |
| author_sort | Annette Rebel |
| collection | DOAJ |
| description | BACKGROUND: The effectiveness of intrathecal opioids (ITOs) for postoperative analgesia has been limited by reduced opioid dosing because of opioid-related side effects, most importantly respiratory depression. To overcome these limitations, high-dose intrathecal morphine was combined with a continuous intravenous (IV) postoperative naloxone infusion. The aim of the present chart analysis was to investigate the safety and efficacy of high-dose ITOs combined with IV naloxone compared with IV opioid analgesia alone. |
| format | Article |
| id | doaj-art-6b4b3ce25e0f4df589b451c1066ee83e |
| institution | OA Journals |
| issn | 1203-6765 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-6b4b3ce25e0f4df589b451c1066ee83e2025-08-20T02:23:59ZengWileyPain Research and Management1203-67652011-01-01161192610.1155/2011/691712Retrospective Analysis of High-Dose Intrathecal Morphine for Analgesia after Pelvic SurgeryAnnette Rebel0Paul Sloan1Michael Andrykowski2Department of Anesthesiology, University of Kentucky Medical Center, Lexington, USADepartment of Anesthesiology, University of Kentucky Medical Center, Lexington, USADepartment of Behavioral Sciences, University of Kentucky Medical Center, Lexington, Kentucky, USABACKGROUND: The effectiveness of intrathecal opioids (ITOs) for postoperative analgesia has been limited by reduced opioid dosing because of opioid-related side effects, most importantly respiratory depression. To overcome these limitations, high-dose intrathecal morphine was combined with a continuous intravenous (IV) postoperative naloxone infusion. The aim of the present chart analysis was to investigate the safety and efficacy of high-dose ITOs combined with IV naloxone compared with IV opioid analgesia alone.http://dx.doi.org/10.1155/2011/691712 |
| spellingShingle | Annette Rebel Paul Sloan Michael Andrykowski Retrospective Analysis of High-Dose Intrathecal Morphine for Analgesia after Pelvic Surgery Pain Research and Management |
| title | Retrospective Analysis of High-Dose Intrathecal Morphine for Analgesia after Pelvic Surgery |
| title_full | Retrospective Analysis of High-Dose Intrathecal Morphine for Analgesia after Pelvic Surgery |
| title_fullStr | Retrospective Analysis of High-Dose Intrathecal Morphine for Analgesia after Pelvic Surgery |
| title_full_unstemmed | Retrospective Analysis of High-Dose Intrathecal Morphine for Analgesia after Pelvic Surgery |
| title_short | Retrospective Analysis of High-Dose Intrathecal Morphine for Analgesia after Pelvic Surgery |
| title_sort | retrospective analysis of high dose intrathecal morphine for analgesia after pelvic surgery |
| url | http://dx.doi.org/10.1155/2011/691712 |
| work_keys_str_mv | AT annetterebel retrospectiveanalysisofhighdoseintrathecalmorphineforanalgesiaafterpelvicsurgery AT paulsloan retrospectiveanalysisofhighdoseintrathecalmorphineforanalgesiaafterpelvicsurgery AT michaelandrykowski retrospectiveanalysisofhighdoseintrathecalmorphineforanalgesiaafterpelvicsurgery |