COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE
Abstract. Multiple parameters of immune system were studied in patients with various clinical forms of tickborne encephalitis (TBE). The patients were examined in acute phase of the infection. It is shown that early immunopathogenesis of TBE, in its feverish form, corresponds to general immunologica...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/458 |
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| author | N. V. Krylova G. N. Leonova E. V. Pavlenko T. S. Zaporozhets T. P. Smolina A. K. Gazha D. V. Novikov I. V. Chenzova |
| author_facet | N. V. Krylova G. N. Leonova E. V. Pavlenko T. S. Zaporozhets T. P. Smolina A. K. Gazha D. V. Novikov I. V. Chenzova |
| author_sort | N. V. Krylova |
| collection | DOAJ |
| description | Abstract. Multiple parameters of immune system were studied in patients with various clinical forms of tickborne encephalitis (TBE). The patients were examined in acute phase of the infection. It is shown that early immunopathogenesis of TBE, in its feverish form, corresponds to general immunological mechanisms of viral infection. Meanwhile, in focal clinical forms of TBE with favorable outcome, we revealed a deficiency of T-cell immunity, disimmunoglobulinemia, and low Th1-cytokine production. In a focal form with fatal outcome, an early hyperproduction of Th1-cytokines and complement components, as well as increased numbers of activated T-lymphocytes have been noted, along with reduced levels of cytotoxic lymphocytes. The changes observed may be considered as early prognostic criteria of a severe infection. |
| format | Article |
| id | doaj-art-6b4a9ef56d36436db9432a38c2f299da |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-6b4a9ef56d36436db9432a38c2f299da2025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01144-531332010.15789/1563-0625-2012-4-5-313-320455COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASEN. V. Krylova0G. N. Leonova1E. V. Pavlenko2T. S. Zaporozhets3T. P. Smolina4A. K. Gazha5D. V. Novikov6I. V. Chenzova7НИИ эпидемиологии и микробиологии СО РАМН, г. ВладивостокНИИ эпидемиологии и микробиологии СО РАМН, г. ВладивостокНИИ эпидемиологии и микробиологии СО РАМН, г. ВладивостокНИИ эпидемиологии и микробиологии СО РАМН, г. ВладивостокНИИ эпидемиологии и микробиологии СО РАМН, г. ВладивостокНИИ эпидемиологии и микробиологии СО РАМН, г. ВладивостокГУЗ Приморская краевая клиническая больница № 1, г. ВладивостокГУЗ Приморская краевая клиническая больница № 1, г. ВладивостокAbstract. Multiple parameters of immune system were studied in patients with various clinical forms of tickborne encephalitis (TBE). The patients were examined in acute phase of the infection. It is shown that early immunopathogenesis of TBE, in its feverish form, corresponds to general immunological mechanisms of viral infection. Meanwhile, in focal clinical forms of TBE with favorable outcome, we revealed a deficiency of T-cell immunity, disimmunoglobulinemia, and low Th1-cytokine production. In a focal form with fatal outcome, an early hyperproduction of Th1-cytokines and complement components, as well as increased numbers of activated T-lymphocytes have been noted, along with reduced levels of cytotoxic lymphocytes. The changes observed may be considered as early prognostic criteria of a severe infection.https://www.mimmun.ru/mimmun/article/view/458tick-borne encephalitisimmunopathogenesis |
| spellingShingle | N. V. Krylova G. N. Leonova E. V. Pavlenko T. S. Zaporozhets T. P. Smolina A. K. Gazha D. V. Novikov I. V. Chenzova COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE Медицинская иммунология tick-borne encephalitis immunopathogenesis |
| title | COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE |
| title_full | COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE |
| title_fullStr | COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE |
| title_full_unstemmed | COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE |
| title_short | COMPREHENSIVE ASSESSMENT OF IMMUNE SYSTEM IN VARIOUS FORMS OF TICK-BORNE ENCEPHALITIS IN ACUTE PHASE |
| title_sort | comprehensive assessment of immune system in various forms of tick borne encephalitis in acute phase |
| topic | tick-borne encephalitis immunopathogenesis |
| url | https://www.mimmun.ru/mimmun/article/view/458 |
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