CXCR5 engineered human and murine Tregs for targeted suppression in secondary and tertiary lymphoid organs

CXCR5 engineered human and murine Tregs for targeted suppression in secondary and tertiary lymphoid organs

IntroductionSecondary and tertiary lymphoid structures are a critical target of suppression in many autoimmune disorders, protein replacement therapies, and in transplantation. Although antigen-specific regulatory T cells (Tregs), such as chimeric antigen receptor (CAR) Tregs, generally persist long...

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Main Authors: Matteo Doglio, Jyoti Rana, Adriana Stucchi, Maite-Muñoz Melero, Alessia Ugolini, Tatiana Jofra, Cristiano Toma, Clara Bercher-Brayer, Pierluigi Carulli, Sandeep Kumar, Paolo Monti, Elisa Martini, Senthilkumar Thirumurugan, Moanaro Biswas, Chiara Bonini, Georgia Fousteri
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
regulatory T cells (Tregs)
C-X-C chemokine receptor type 5 (CXCR5)
type 1 diabetes (T1D)
pancreatic islet transplantation
hemophilia
chimeric antigen receptor (CAR)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1513009/full
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