New Perspectives on the Impact of Iron Chelation Therapy on the Gut Microbiome in Thalassemia Patients
Thalassemia, a genetic condition characterized by defective hemoglobin synthesis, is often managed with transfusion therapy, which can lead to iron overload—a significant contributor to morbidity and mortality due to organ damage and pathogenic infections. Iron chelation therapy, the cornerstone of...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
|
| Series: | Thalassemia Reports |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2039-4365/15/1/2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850280012471599104 |
|---|---|
| author | Sara Deumić Neira Crnčević Mirsada Hukić Muamer Dizdar Monia Avdić |
| author_facet | Sara Deumić Neira Crnčević Mirsada Hukić Muamer Dizdar Monia Avdić |
| author_sort | Sara Deumić |
| collection | DOAJ |
| description | Thalassemia, a genetic condition characterized by defective hemoglobin synthesis, is often managed with transfusion therapy, which can lead to iron overload—a significant contributor to morbidity and mortality due to organ damage and pathogenic infections. Iron chelation therapy, the cornerstone of managing iron toxicity, may inadvertently influence the gut microbiome, a critical modulator of immunity and metabolism. This review provides new insights into the interplay between iron chelation therapy and gut microbiome dynamics in thalassemia patients. It synthesizes findings on how chelators such as deferoxamine, deferasirox, and deferiprone influence microbial composition, iron availability, and systemic inflammation. Emerging evidence highlights alterations in gut microbial diversity, with reduced beneficial taxa and increased pathogenic populations, driven by changes in luminal iron levels. This imbalance contributes to immune dysregulation, systemic inflammation, and susceptibility to infections. The review advocates for tailored treatment strategies that integrate microbiome-targeted interventions alongside traditional chelation therapy to improve patient outcomes. By combining genetic profiling, dietary adjustments, and microbiome modulation, this approach offers a promising avenue for personalized medicine in thalassemia care. |
| format | Article |
| id | doaj-art-6b3744e091ec457c80cf6b136fa9a16d |
| institution | OA Journals |
| issn | 2039-4365 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Thalassemia Reports |
| spelling | doaj-art-6b3744e091ec457c80cf6b136fa9a16d2025-08-20T01:48:54ZengMDPI AGThalassemia Reports2039-43652025-02-01151210.3390/thalassrep15010002New Perspectives on the Impact of Iron Chelation Therapy on the Gut Microbiome in Thalassemia PatientsSara Deumić0Neira Crnčević1Mirsada Hukić2Muamer Dizdar3Monia Avdić4Department of Genetics and Bioengineering, International Burch University, Francuske Revolucije bb, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Genetics and Bioengineering, International Burch University, Francuske Revolucije bb, 71000 Sarajevo, Bosnia and HerzegovinaAcademy of Sciences and Arts of Bosnia and Herzegovina, Center for Disease Control and Geohealth Studies, Bistrik 7, 71000 Sarajevo, Bosnia and HerzegovinaFaculty of Science, University of Sarajevo, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Genetics and Bioengineering, International Burch University, Francuske Revolucije bb, 71000 Sarajevo, Bosnia and HerzegovinaThalassemia, a genetic condition characterized by defective hemoglobin synthesis, is often managed with transfusion therapy, which can lead to iron overload—a significant contributor to morbidity and mortality due to organ damage and pathogenic infections. Iron chelation therapy, the cornerstone of managing iron toxicity, may inadvertently influence the gut microbiome, a critical modulator of immunity and metabolism. This review provides new insights into the interplay between iron chelation therapy and gut microbiome dynamics in thalassemia patients. It synthesizes findings on how chelators such as deferoxamine, deferasirox, and deferiprone influence microbial composition, iron availability, and systemic inflammation. Emerging evidence highlights alterations in gut microbial diversity, with reduced beneficial taxa and increased pathogenic populations, driven by changes in luminal iron levels. This imbalance contributes to immune dysregulation, systemic inflammation, and susceptibility to infections. The review advocates for tailored treatment strategies that integrate microbiome-targeted interventions alongside traditional chelation therapy to improve patient outcomes. By combining genetic profiling, dietary adjustments, and microbiome modulation, this approach offers a promising avenue for personalized medicine in thalassemia care.https://www.mdpi.com/2039-4365/15/1/2thalassemiairon chelationiron overloadmicrobiome |
| spellingShingle | Sara Deumić Neira Crnčević Mirsada Hukić Muamer Dizdar Monia Avdić New Perspectives on the Impact of Iron Chelation Therapy on the Gut Microbiome in Thalassemia Patients Thalassemia Reports thalassemia iron chelation iron overload microbiome |
| title | New Perspectives on the Impact of Iron Chelation Therapy on the Gut Microbiome in Thalassemia Patients |
| title_full | New Perspectives on the Impact of Iron Chelation Therapy on the Gut Microbiome in Thalassemia Patients |
| title_fullStr | New Perspectives on the Impact of Iron Chelation Therapy on the Gut Microbiome in Thalassemia Patients |
| title_full_unstemmed | New Perspectives on the Impact of Iron Chelation Therapy on the Gut Microbiome in Thalassemia Patients |
| title_short | New Perspectives on the Impact of Iron Chelation Therapy on the Gut Microbiome in Thalassemia Patients |
| title_sort | new perspectives on the impact of iron chelation therapy on the gut microbiome in thalassemia patients |
| topic | thalassemia iron chelation iron overload microbiome |
| url | https://www.mdpi.com/2039-4365/15/1/2 |
| work_keys_str_mv | AT saradeumic newperspectivesontheimpactofironchelationtherapyonthegutmicrobiomeinthalassemiapatients AT neiracrncevic newperspectivesontheimpactofironchelationtherapyonthegutmicrobiomeinthalassemiapatients AT mirsadahukic newperspectivesontheimpactofironchelationtherapyonthegutmicrobiomeinthalassemiapatients AT muamerdizdar newperspectivesontheimpactofironchelationtherapyonthegutmicrobiomeinthalassemiapatients AT moniaavdic newperspectivesontheimpactofironchelationtherapyonthegutmicrobiomeinthalassemiapatients |