Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer?
Heme is a compound consisting of an iron (Fe) atom bound to a pyrrole ring forming protoporphyrin IX (PPIX). Protoporphyrin combines with a protein-forming hemoprotein compound that plays an essential role in oxygen-binding and transport as well as in the process of energy production in the mitocho...
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| Format: | Article |
| Language: | English |
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Indonesian Society for Biochemistry and Molecular Biology
2022-12-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/65 |
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| _version_ | 1825199575400448000 |
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| author | Raisa Nauli Sri Widia A Jusman |
| author_facet | Raisa Nauli Sri Widia A Jusman |
| author_sort | Raisa Nauli |
| collection | DOAJ |
| description |
Heme is a compound consisting of an iron (Fe) atom bound to a pyrrole ring forming protoporphyrin IX (PPIX). Protoporphyrin combines with a protein-forming hemoprotein compound that plays an essential role in oxygen-binding and transport as well as in the process of energy production in the mitochondria. Some cancer cells have more heme biosynthesis than normal cells, which is thought to be linked to more cancer cell growth. Inhibition of heme biosynthesis in some cancer cells leads to decreased cell proliferation. This review article discusses the synthesis of heme, the role of heme in energy metabolism, which is needed for cell proliferation, the inhibition of heme synthesis and its effect on cancer cell proliferation, and the possibility of the inhibition of heme biosynthesis as an approach in therapy of cancer in the future.
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| format | Article |
| id | doaj-art-6b34d0f839614888bf920273e99acb20 |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-6b34d0f839614888bf920273e99acb202025-02-08T03:05:58ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222022-12-015210.32889/actabioina.65Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer? Raisa Nauli0Sri Widia A Jusman1Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaDepartment of Biochemistry & Molecular Biology, Faculty of Medicine, Universitas Indonesia Heme is a compound consisting of an iron (Fe) atom bound to a pyrrole ring forming protoporphyrin IX (PPIX). Protoporphyrin combines with a protein-forming hemoprotein compound that plays an essential role in oxygen-binding and transport as well as in the process of energy production in the mitochondria. Some cancer cells have more heme biosynthesis than normal cells, which is thought to be linked to more cancer cell growth. Inhibition of heme biosynthesis in some cancer cells leads to decreased cell proliferation. This review article discusses the synthesis of heme, the role of heme in energy metabolism, which is needed for cell proliferation, the inhibition of heme synthesis and its effect on cancer cell proliferation, and the possibility of the inhibition of heme biosynthesis as an approach in therapy of cancer in the future. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/65heme biosynthesishemoproteininhibition of heme biosynthesiscancer cell proliferation |
| spellingShingle | Raisa Nauli Sri Widia A Jusman Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer? Acta Biochimica Indonesiana heme biosynthesis hemoprotein inhibition of heme biosynthesis cancer cell proliferation |
| title | Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer? |
| title_full | Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer? |
| title_fullStr | Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer? |
| title_full_unstemmed | Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer? |
| title_short | Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer? |
| title_sort | is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer |
| topic | heme biosynthesis hemoprotein inhibition of heme biosynthesis cancer cell proliferation |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/65 |
| work_keys_str_mv | AT raisanauli ishemebiosynthesisinfluencedthemitochondrialfunctionandcellproliferationincancer AT sriwidiaajusman ishemebiosynthesisinfluencedthemitochondrialfunctionandcellproliferationincancer |