Immunoregulatory Role of HLA-G in Allergic Diseases
Allergic diseases are sustained by a T-helper 2 polarization leading to interleukin-4 secretion, IgE-dependent inflammation, and mast cell and eosinophil activation. HLA-G molecules, both in membrane-bound and in soluble forms, play a central role in modulation of immune responses. Elevated levels o...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6865758 |
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| author | Giuseppe Murdaca Paola Contini Simone Negrini Giorgio Ciprandi Francesco Puppo |
| author_facet | Giuseppe Murdaca Paola Contini Simone Negrini Giorgio Ciprandi Francesco Puppo |
| author_sort | Giuseppe Murdaca |
| collection | DOAJ |
| description | Allergic diseases are sustained by a T-helper 2 polarization leading to interleukin-4 secretion, IgE-dependent inflammation, and mast cell and eosinophil activation. HLA-G molecules, both in membrane-bound and in soluble forms, play a central role in modulation of immune responses. Elevated levels of soluble HLA-G (sHLA-G) molecules are detected in serum of patients with allergic rhinitis to seasonal and perennial allergens and correlate with allergen-specific IgE levels, clinical severity, drug consumption, and response to allergen-specific immunotherapy. sHLA-G molecules are also found in airway epithelium of patients with allergic asthma and high levels of sHLA-G molecules are detectable in plasma and bronchoalveolar lavage of asthmatic patients correlating with allergen-specific IgE levels. Finally, HLA-G molecules are expressed by T cells, monocytes-macrophages, and Langerhans cells infiltrating the dermis of atopic dermatitis patients. Collectively, although at present it is difficult to completely define the role of HLA-G molecules in allergic diseases, it may be suggested that they are expressed and secreted by immune cells during the allergic reaction in an attempt to suppress allergic inflammation. |
| format | Article |
| id | doaj-art-6b2b32a7dba3442ea36e54d79d3479bc |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-6b2b32a7dba3442ea36e54d79d3479bc2025-08-20T02:23:57ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/68657586865758Immunoregulatory Role of HLA-G in Allergic DiseasesGiuseppe Murdaca0Paola Contini1Simone Negrini2Giorgio Ciprandi3Francesco Puppo4Department of Internal Medicine, Scleroderma Unit, Clinical Immunology Unit, University of Genova, 16132 Genova, ItalyDepartment of Internal Medicine, Scleroderma Unit, Clinical Immunology Unit, University of Genova, 16132 Genova, ItalyDepartment of Internal Medicine, Scleroderma Unit, Clinical Immunology Unit, University of Genova, 16132 Genova, ItalyDepartment of Internal Medicine, Respiratory and Allergy Diseases Unit, University of Genova, 16132 Genova, ItalyDepartment of Internal Medicine, Scleroderma Unit, Clinical Immunology Unit, University of Genova, 16132 Genova, ItalyAllergic diseases are sustained by a T-helper 2 polarization leading to interleukin-4 secretion, IgE-dependent inflammation, and mast cell and eosinophil activation. HLA-G molecules, both in membrane-bound and in soluble forms, play a central role in modulation of immune responses. Elevated levels of soluble HLA-G (sHLA-G) molecules are detected in serum of patients with allergic rhinitis to seasonal and perennial allergens and correlate with allergen-specific IgE levels, clinical severity, drug consumption, and response to allergen-specific immunotherapy. sHLA-G molecules are also found in airway epithelium of patients with allergic asthma and high levels of sHLA-G molecules are detectable in plasma and bronchoalveolar lavage of asthmatic patients correlating with allergen-specific IgE levels. Finally, HLA-G molecules are expressed by T cells, monocytes-macrophages, and Langerhans cells infiltrating the dermis of atopic dermatitis patients. Collectively, although at present it is difficult to completely define the role of HLA-G molecules in allergic diseases, it may be suggested that they are expressed and secreted by immune cells during the allergic reaction in an attempt to suppress allergic inflammation.http://dx.doi.org/10.1155/2016/6865758 |
| spellingShingle | Giuseppe Murdaca Paola Contini Simone Negrini Giorgio Ciprandi Francesco Puppo Immunoregulatory Role of HLA-G in Allergic Diseases Journal of Immunology Research |
| title | Immunoregulatory Role of HLA-G in Allergic Diseases |
| title_full | Immunoregulatory Role of HLA-G in Allergic Diseases |
| title_fullStr | Immunoregulatory Role of HLA-G in Allergic Diseases |
| title_full_unstemmed | Immunoregulatory Role of HLA-G in Allergic Diseases |
| title_short | Immunoregulatory Role of HLA-G in Allergic Diseases |
| title_sort | immunoregulatory role of hla g in allergic diseases |
| url | http://dx.doi.org/10.1155/2016/6865758 |
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