A Case of Neurally Mediated Syncope and Sick Sinus Syndrome Associated With Lung Cancer

We describe a case of non–small cell lung cancer (NSCLC) associated with recurrent episodes of syncope. During the work-up for syncope, the patient was incidentally found to have a mass in the right upper lobe, which was later diagnosed as NSCLC. Positron emission tomography computed tomography show...

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Main Authors: Shihomi Kirihara, Shoji Kawakami, Jun-ichiro Nishi
Format: Article
Language:English
Published: American College of Physicians 2025-03-01
Series:Annals of Internal Medicine: Clinical Cases
Online Access:https://www.acpjournals.org/doi/10.7326/aimcc.2024.0865
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author Shihomi Kirihara
Shoji Kawakami
Jun-ichiro Nishi
author_facet Shihomi Kirihara
Shoji Kawakami
Jun-ichiro Nishi
author_sort Shihomi Kirihara
collection DOAJ
description We describe a case of non–small cell lung cancer (NSCLC) associated with recurrent episodes of syncope. During the work-up for syncope, the patient was incidentally found to have a mass in the right upper lobe, which was later diagnosed as NSCLC. Positron emission tomography computed tomography showed metastatic lymphadenopathy of the supraclavicular and paratracheal nodes involving the cardiac branches of the vagus nerve. The patient no longer experienced syncope after starting immunochemotherapy. Considering the rapid and complete remission of syncope after the treatment of lung cancer and the location of metastatic lymphadenopathy, this condition might represent a location-dependent syndrome.
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record_format Article
series Annals of Internal Medicine: Clinical Cases
spelling doaj-art-6b24eef4299a4f0cbc4fb6406445f10b2025-08-20T02:27:20ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642025-03-014310.7326/aimcc.2024.0865A Case of Neurally Mediated Syncope and Sick Sinus Syndrome Associated With Lung CancerShihomi Kirihara0Shoji Kawakami1Jun-ichiro Nishi21Department of Cardiology, Aso Iizuka Hospital, Iizuka, Japan1Department of Cardiology, Aso Iizuka Hospital, Iizuka, Japan1Department of Cardiology, Aso Iizuka Hospital, Iizuka, JapanWe describe a case of non–small cell lung cancer (NSCLC) associated with recurrent episodes of syncope. During the work-up for syncope, the patient was incidentally found to have a mass in the right upper lobe, which was later diagnosed as NSCLC. Positron emission tomography computed tomography showed metastatic lymphadenopathy of the supraclavicular and paratracheal nodes involving the cardiac branches of the vagus nerve. The patient no longer experienced syncope after starting immunochemotherapy. Considering the rapid and complete remission of syncope after the treatment of lung cancer and the location of metastatic lymphadenopathy, this condition might represent a location-dependent syndrome.https://www.acpjournals.org/doi/10.7326/aimcc.2024.0865
spellingShingle Shihomi Kirihara
Shoji Kawakami
Jun-ichiro Nishi
A Case of Neurally Mediated Syncope and Sick Sinus Syndrome Associated With Lung Cancer
Annals of Internal Medicine: Clinical Cases
title A Case of Neurally Mediated Syncope and Sick Sinus Syndrome Associated With Lung Cancer
title_full A Case of Neurally Mediated Syncope and Sick Sinus Syndrome Associated With Lung Cancer
title_fullStr A Case of Neurally Mediated Syncope and Sick Sinus Syndrome Associated With Lung Cancer
title_full_unstemmed A Case of Neurally Mediated Syncope and Sick Sinus Syndrome Associated With Lung Cancer
title_short A Case of Neurally Mediated Syncope and Sick Sinus Syndrome Associated With Lung Cancer
title_sort case of neurally mediated syncope and sick sinus syndrome associated with lung cancer
url https://www.acpjournals.org/doi/10.7326/aimcc.2024.0865
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