Crosstalk between Epigenetics and Autophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease, is one of the most common causes of liver dysfunction worldwide, posing a significant economic burden. However, our understanding of the cellular and molecular mechanisms underlyi...
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| Format: | Article |
| Language: | English |
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Korean Society for the Study of Obesity
2025-07-01
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| Series: | Journal of Obesity & Metabolic Syndrome |
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| Online Access: | http://www.jomes.org/journal/view.html?doi=10.7570/jomes24041 |
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| author | Irfana Zahoor Gh Jeelani Mir Nazir Ahmad Lone Nissar Ul Ashraf |
| author_facet | Irfana Zahoor Gh Jeelani Mir Nazir Ahmad Lone Nissar Ul Ashraf |
| author_sort | Irfana Zahoor |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease, is one of the most common causes of liver dysfunction worldwide, posing a significant economic burden. However, our understanding of the cellular and molecular mechanisms underlying the pathogenesis of MASLD is in its early stages. Over the last two decades, epigenetic mechanisms and autophagy have emerged as two independent phenomena that control cellular and molecular processes in health and disease. Epigenetic events and defects in autophagy have been linked with the pathogenesis of MASLD and metabolic dysfunction-associated steatohepatitis (MASH) in cellular studies, mouse models, and human research. However, the connection between epigenetic mechanisms and autophagy regulation in MASLD and MASH pathogenesis remains unclear. This review highlights the importance of epigenetic modifications and their regulatory switches in controlling downstream pathways that significantly impact metabolic disease pathogenesis. We also review the need to identify key epigenetic factors regulating autophagy in MASLD and MASH pathogenesis. Such insights could aid the development of novel strategies to restore autophagy and improve disease outcomes. |
| format | Article |
| id | doaj-art-6b244487019c402496af3cbfa5ef5474 |
| institution | DOAJ |
| issn | 2508-6235 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Korean Society for the Study of Obesity |
| record_format | Article |
| series | Journal of Obesity & Metabolic Syndrome |
| spelling | doaj-art-6b244487019c402496af3cbfa5ef54742025-08-20T02:46:06ZengKorean Society for the Study of ObesityJournal of Obesity & Metabolic Syndrome2508-62352025-07-0134325326710.7570/jomes24041jomes24041Crosstalk between Epigenetics and Autophagy in Metabolic Dysfunction-Associated Steatotic Liver DiseaseIrfana Zahoor0Gh Jeelani Mir1Nazir Ahmad Lone2Nissar Ul Ashraf3Departmemt of Biochemistry, Government College for Women, Nawakadal Srinagar, Jammu & Kashmir, IndiaDepartment of Clinical Biochemistry, Government Degree College Sopore, Jammu & Kashmir, IndiaDepartment of Biotechnology, Government College for Women, Nawakadal Srinagar, Jammu & Kashmir, IndiaDepartmemt of Biochemistry, Government College for Women, Nawakadal Srinagar, Jammu & Kashmir, IndiaMetabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease, is one of the most common causes of liver dysfunction worldwide, posing a significant economic burden. However, our understanding of the cellular and molecular mechanisms underlying the pathogenesis of MASLD is in its early stages. Over the last two decades, epigenetic mechanisms and autophagy have emerged as two independent phenomena that control cellular and molecular processes in health and disease. Epigenetic events and defects in autophagy have been linked with the pathogenesis of MASLD and metabolic dysfunction-associated steatohepatitis (MASH) in cellular studies, mouse models, and human research. However, the connection between epigenetic mechanisms and autophagy regulation in MASLD and MASH pathogenesis remains unclear. This review highlights the importance of epigenetic modifications and their regulatory switches in controlling downstream pathways that significantly impact metabolic disease pathogenesis. We also review the need to identify key epigenetic factors regulating autophagy in MASLD and MASH pathogenesis. Such insights could aid the development of novel strategies to restore autophagy and improve disease outcomes.http://www.jomes.org/journal/view.html?doi=10.7570/jomes24041metabolic dysfunction-associated steatotic liver diseasemetabolic dysfunction-associated steatohepatitisautophagychromatindna methylationhistone methylationhistone acetylation |
| spellingShingle | Irfana Zahoor Gh Jeelani Mir Nazir Ahmad Lone Nissar Ul Ashraf Crosstalk between Epigenetics and Autophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease Journal of Obesity & Metabolic Syndrome metabolic dysfunction-associated steatotic liver disease metabolic dysfunction-associated steatohepatitis autophagy chromatin dna methylation histone methylation histone acetylation |
| title | Crosstalk between Epigenetics and Autophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_full | Crosstalk between Epigenetics and Autophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_fullStr | Crosstalk between Epigenetics and Autophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_full_unstemmed | Crosstalk between Epigenetics and Autophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_short | Crosstalk between Epigenetics and Autophagy in Metabolic Dysfunction-Associated Steatotic Liver Disease |
| title_sort | crosstalk between epigenetics and autophagy in metabolic dysfunction associated steatotic liver disease |
| topic | metabolic dysfunction-associated steatotic liver disease metabolic dysfunction-associated steatohepatitis autophagy chromatin dna methylation histone methylation histone acetylation |
| url | http://www.jomes.org/journal/view.html?doi=10.7570/jomes24041 |
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