The synergy of TPL and selinexor in MLL-R acute myeloid leukemia via Rap1/Raf/MEK pathway-mediated MYC downregulation

The synergy of TPL and selinexor in MLL-R acute myeloid leukemia via Rap1/Raf/MEK pathway-mediated MYC downregulation

MLL gene rearrangement recurrently occurs in acute myeloid leukemia (MLL-r AML), which is closely associated with chemotherapy insensitivity and unfavorable clinical outcomes. More importantly, there are limited therapeutic options for the management of patients with MLL-r AML, thus necessitating no...

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Bibliographic Details
Main Authors: Manman Deng, Peicui Huang, Lijuan Wang, Yuelong Jiang, Zhenling Guo, Hongpeng Duan, Jie Zha, Haijun Zhao, Guowei Li, Bing Xu
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Translational Oncology
Subjects:
MLL rearrangement (MLL-r)
Acute myeloid leukemia (AML)
Triptolide
XPO1 inhibitor selinexor
Synergy
MYC
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001305
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