Effects of central metals on sugar decorated tetrakis-(4-methylthiophenyl) porphyrin considered for use in photodynamic therapy
This study focuses on the synthesis of sugar decorated porphyrins and their gold nanoparticle conjugates as photosensitizers for photodynamic therapy (PDT). Linking the sugar to the porphyrins imparted water solubility to the latter. The conjugation to sugar molecules enhanced the singlet oxygen qua...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
|
| Series: | Photodiagnosis and Photodynamic Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025001905 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849240218064912384 |
|---|---|
| author | Thembani Silas Vukeya Refilwe Matshitse John Mack Yolande Openda Earl Prinsloo Tebello Nyokong |
| author_facet | Thembani Silas Vukeya Refilwe Matshitse John Mack Yolande Openda Earl Prinsloo Tebello Nyokong |
| author_sort | Thembani Silas Vukeya |
| collection | DOAJ |
| description | This study focuses on the synthesis of sugar decorated porphyrins and their gold nanoparticle conjugates as photosensitizers for photodynamic therapy (PDT). Linking the sugar to the porphyrins imparted water solubility to the latter. The conjugation to sugar molecules enhanced the singlet oxygen quantum yield and improved the cellular uptake and therefore, their phototoxicity in some cases. The porphyrins (with or without the sugar) were linked to the Au nanoparticles (AuNPs). The activity of the synthesized complexes and conjugates with AuNPs were tested against the MDA-MB-231 breast cancer cells using the resazurin assay to monitor the cell viability. The conjugate of In porphyrin with AuNPs showed the highest PDT activity. |
| format | Article |
| id | doaj-art-6b1e771cad3448cc892c26ea711c8a31 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-6b1e771cad3448cc892c26ea711c8a312025-08-20T04:00:40ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-08-015410465810.1016/j.pdpdt.2025.104658Effects of central metals on sugar decorated tetrakis-(4-methylthiophenyl) porphyrin considered for use in photodynamic therapyThembani Silas Vukeya0Refilwe Matshitse1John Mack2Yolande Openda3Earl Prinsloo4Tebello Nyokong5Institute for Nanotechnology Innovation, Rhodes University, Makhanda, South AfricaInstitute for Nanotechnology Innovation, Rhodes University, Makhanda, South AfricaInstitute for Nanotechnology Innovation, Rhodes University, Makhanda, South AfricaInstitute for Nanotechnology Innovation, Rhodes University, Makhanda, South AfricaBiotechnology Innovation Centre, Rhodes University, Makhanda, South AfricaInstitute for Nanotechnology Innovation, Rhodes University, Makhanda, South Africa; Corresponding author.This study focuses on the synthesis of sugar decorated porphyrins and their gold nanoparticle conjugates as photosensitizers for photodynamic therapy (PDT). Linking the sugar to the porphyrins imparted water solubility to the latter. The conjugation to sugar molecules enhanced the singlet oxygen quantum yield and improved the cellular uptake and therefore, their phototoxicity in some cases. The porphyrins (with or without the sugar) were linked to the Au nanoparticles (AuNPs). The activity of the synthesized complexes and conjugates with AuNPs were tested against the MDA-MB-231 breast cancer cells using the resazurin assay to monitor the cell viability. The conjugate of In porphyrin with AuNPs showed the highest PDT activity.http://www.sciencedirect.com/science/article/pii/S1572100025001905Photodynamic therapyPhotosensitizerReactive oxygen speciesSinglet oxygenGold nanoparticlesSugar |
| spellingShingle | Thembani Silas Vukeya Refilwe Matshitse John Mack Yolande Openda Earl Prinsloo Tebello Nyokong Effects of central metals on sugar decorated tetrakis-(4-methylthiophenyl) porphyrin considered for use in photodynamic therapy Photodiagnosis and Photodynamic Therapy Photodynamic therapy Photosensitizer Reactive oxygen species Singlet oxygen Gold nanoparticles Sugar |
| title | Effects of central metals on sugar decorated tetrakis-(4-methylthiophenyl) porphyrin considered for use in photodynamic therapy |
| title_full | Effects of central metals on sugar decorated tetrakis-(4-methylthiophenyl) porphyrin considered for use in photodynamic therapy |
| title_fullStr | Effects of central metals on sugar decorated tetrakis-(4-methylthiophenyl) porphyrin considered for use in photodynamic therapy |
| title_full_unstemmed | Effects of central metals on sugar decorated tetrakis-(4-methylthiophenyl) porphyrin considered for use in photodynamic therapy |
| title_short | Effects of central metals on sugar decorated tetrakis-(4-methylthiophenyl) porphyrin considered for use in photodynamic therapy |
| title_sort | effects of central metals on sugar decorated tetrakis 4 methylthiophenyl porphyrin considered for use in photodynamic therapy |
| topic | Photodynamic therapy Photosensitizer Reactive oxygen species Singlet oxygen Gold nanoparticles Sugar |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025001905 |
| work_keys_str_mv | AT thembanisilasvukeya effectsofcentralmetalsonsugardecoratedtetrakis4methylthiophenylporphyrinconsideredforuseinphotodynamictherapy AT refilwematshitse effectsofcentralmetalsonsugardecoratedtetrakis4methylthiophenylporphyrinconsideredforuseinphotodynamictherapy AT johnmack effectsofcentralmetalsonsugardecoratedtetrakis4methylthiophenylporphyrinconsideredforuseinphotodynamictherapy AT yolandeopenda effectsofcentralmetalsonsugardecoratedtetrakis4methylthiophenylporphyrinconsideredforuseinphotodynamictherapy AT earlprinsloo effectsofcentralmetalsonsugardecoratedtetrakis4methylthiophenylporphyrinconsideredforuseinphotodynamictherapy AT tebellonyokong effectsofcentralmetalsonsugardecoratedtetrakis4methylthiophenylporphyrinconsideredforuseinphotodynamictherapy |