Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture
Smoking is an established risk factor for subarachnoid hemorrhage yet the underlying mechanisms are largely unknown. Recent data has implicated a role of inflammation in the development of cerebral aneurysms. Inflammation accompanying cigarette smoke exposure may thus be a critical pathway underlyin...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/271582 |
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| _version_ | 1849413896924823552 |
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| author | Nohra Chalouhi Muhammad S. Ali Robert M. Starke Pascal M. Jabbour Stavropoula I. Tjoumakaris L. Fernando Gonzalez Robert H. Rosenwasser Walter J. Koch Aaron S. Dumont |
| author_facet | Nohra Chalouhi Muhammad S. Ali Robert M. Starke Pascal M. Jabbour Stavropoula I. Tjoumakaris L. Fernando Gonzalez Robert H. Rosenwasser Walter J. Koch Aaron S. Dumont |
| author_sort | Nohra Chalouhi |
| collection | DOAJ |
| description | Smoking is an established risk factor for subarachnoid hemorrhage yet the underlying mechanisms are largely unknown. Recent data has implicated a role of inflammation in the development of cerebral aneurysms. Inflammation accompanying cigarette smoke exposure may thus be a critical pathway underlying the development, progression, and rupture of cerebral aneurysms. Various constituents of the inflammatory response appear to be involved including adhesion molecules, cytokines, reactive oxygen species, leukocytes, matrix metalloproteinases, and vascular smooth muscle cells. Characterization of the molecular basis of the inflammatory response accompanying cigarette smoke exposure will provide a rational approach for future targeted therapy. In this paper, we review the current body of knowledge implicating cigarette smoke-induced inflammation in cerebral aneurysm formation/rupture and attempt to highlight important avenues for future investigation. |
| format | Article |
| id | doaj-art-6b1686b771bc4e18b984eaf9d9c12a5c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6b1686b771bc4e18b984eaf9d9c12a5c2025-08-20T03:34:00ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/271582271582Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and RuptureNohra Chalouhi0Muhammad S. Ali1Robert M. Starke2Pascal M. Jabbour3Stavropoula I. Tjoumakaris4L. Fernando Gonzalez5Robert H. Rosenwasser6Walter J. Koch7Aaron S. Dumont8Joseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular & Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USAJoseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular & Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, VA 22903, USAJoseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular & Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USAJoseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular & Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USAJoseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular & Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USAJoseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular & Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USACenter for Translational Medicine and George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USAJoseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular & Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USASmoking is an established risk factor for subarachnoid hemorrhage yet the underlying mechanisms are largely unknown. Recent data has implicated a role of inflammation in the development of cerebral aneurysms. Inflammation accompanying cigarette smoke exposure may thus be a critical pathway underlying the development, progression, and rupture of cerebral aneurysms. Various constituents of the inflammatory response appear to be involved including adhesion molecules, cytokines, reactive oxygen species, leukocytes, matrix metalloproteinases, and vascular smooth muscle cells. Characterization of the molecular basis of the inflammatory response accompanying cigarette smoke exposure will provide a rational approach for future targeted therapy. In this paper, we review the current body of knowledge implicating cigarette smoke-induced inflammation in cerebral aneurysm formation/rupture and attempt to highlight important avenues for future investigation.http://dx.doi.org/10.1155/2012/271582 |
| spellingShingle | Nohra Chalouhi Muhammad S. Ali Robert M. Starke Pascal M. Jabbour Stavropoula I. Tjoumakaris L. Fernando Gonzalez Robert H. Rosenwasser Walter J. Koch Aaron S. Dumont Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture Mediators of Inflammation |
| title | Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture |
| title_full | Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture |
| title_fullStr | Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture |
| title_full_unstemmed | Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture |
| title_short | Cigarette Smoke and Inflammation: Role in Cerebral Aneurysm Formation and Rupture |
| title_sort | cigarette smoke and inflammation role in cerebral aneurysm formation and rupture |
| url | http://dx.doi.org/10.1155/2012/271582 |
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