Modeling of functional ovarian cysts by introducing a follicle-stimulating hormone
Aim. To study the morphofunctional state of ovaries after the introduction of recombinant FSH. Materials and methods. Two groups of mature female Wistar rats were used in the study. The experimental group consisted of 35 rats with a model of follicular ovarian cysts, while 25 rats were in the contro...
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Siberian State Medical University (Tomsk)
2017-10-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/964 |
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| author | Daria A. Trus Olga A. Tikhonovskaya Aleksandr O. Okorokov Liliya R. Mustafina O. S. Timofeeva Sergey V. Logvinov Alexandr V. Gerasimov Elena Yu. Varakuta Aleksey V. Potapov Galina A. Suhanova Irina G. Kutsenko |
| author_facet | Daria A. Trus Olga A. Tikhonovskaya Aleksandr O. Okorokov Liliya R. Mustafina O. S. Timofeeva Sergey V. Logvinov Alexandr V. Gerasimov Elena Yu. Varakuta Aleksey V. Potapov Galina A. Suhanova Irina G. Kutsenko |
| author_sort | Daria A. Trus |
| collection | DOAJ |
| description | Aim. To study the morphofunctional state of ovaries after the introduction of recombinant FSH. Materials and methods. Two groups of mature female Wistar rats were used in the study. The experimental group consisted of 35 rats with a model of follicular ovarian cysts, while 25 rats were in the control group.Rats were taken out of the experiment on days 3, 7, 15, 30 and 60. Paraffin slides of ovaries were stained with hematoxylin and eosin by Van Gieson. Histological and morphometric investigations were performed.Results. On day 7 of FSH administration, the maximum increase in the size of the ovaries was observed due to the formation of single-cell follicular cysts. Rats in the experimental group showed a marked decrease in the number of growing follicles on day 7 and 15. The increase in atretic bodies and follicles in comparison with the control group was observed on day 7 and lasted until the end of the experiment. Additionally, on day 7 of the experiment, hyperemia and vasoconstriction were noted. The number of yellow bodies decreased during the experiment, and an increase in collagen formation occurred starting from day 15 of the experiment.Conclusion. The introduction of follicle-stimulating hormone for 7 days leads to disruption of folliculogenesis, strengthening of atresia in the ovaries, and the formation of functional cysts. |
| format | Article |
| id | doaj-art-6b1366398da4452ea8fcf32d794e1cc4 |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-6b1366398da4452ea8fcf32d794e1cc42025-08-20T03:02:05ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842017-10-0116313714410.20538/1682-0363-2017-3-137-144716Modeling of functional ovarian cysts by introducing a follicle-stimulating hormoneDaria A. Trus0Olga A. Tikhonovskaya1Aleksandr O. Okorokov2Liliya R. Mustafina3O. S. Timofeeva4Sergey V. Logvinov5Alexandr V. Gerasimov6Elena Yu. Varakuta7Aleksey V. Potapov8Galina A. Suhanova9Irina G. Kutsenko10Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Siberian State Medical University (SSMU)Aim. To study the morphofunctional state of ovaries after the introduction of recombinant FSH. Materials and methods. Two groups of mature female Wistar rats were used in the study. The experimental group consisted of 35 rats with a model of follicular ovarian cysts, while 25 rats were in the control group.Rats were taken out of the experiment on days 3, 7, 15, 30 and 60. Paraffin slides of ovaries were stained with hematoxylin and eosin by Van Gieson. Histological and morphometric investigations were performed.Results. On day 7 of FSH administration, the maximum increase in the size of the ovaries was observed due to the formation of single-cell follicular cysts. Rats in the experimental group showed a marked decrease in the number of growing follicles on day 7 and 15. The increase in atretic bodies and follicles in comparison with the control group was observed on day 7 and lasted until the end of the experiment. Additionally, on day 7 of the experiment, hyperemia and vasoconstriction were noted. The number of yellow bodies decreased during the experiment, and an increase in collagen formation occurred starting from day 15 of the experiment.Conclusion. The introduction of follicle-stimulating hormone for 7 days leads to disruption of folliculogenesis, strengthening of atresia in the ovaries, and the formation of functional cysts.https://bulletin.ssmu.ru/jour/article/view/964modeling of functional cystsovarian morphologyfunctional ovarian cysts |
| spellingShingle | Daria A. Trus Olga A. Tikhonovskaya Aleksandr O. Okorokov Liliya R. Mustafina O. S. Timofeeva Sergey V. Logvinov Alexandr V. Gerasimov Elena Yu. Varakuta Aleksey V. Potapov Galina A. Suhanova Irina G. Kutsenko Modeling of functional ovarian cysts by introducing a follicle-stimulating hormone Бюллетень сибирской медицины modeling of functional cysts ovarian morphology functional ovarian cysts |
| title | Modeling of functional ovarian cysts by introducing a follicle-stimulating hormone |
| title_full | Modeling of functional ovarian cysts by introducing a follicle-stimulating hormone |
| title_fullStr | Modeling of functional ovarian cysts by introducing a follicle-stimulating hormone |
| title_full_unstemmed | Modeling of functional ovarian cysts by introducing a follicle-stimulating hormone |
| title_short | Modeling of functional ovarian cysts by introducing a follicle-stimulating hormone |
| title_sort | modeling of functional ovarian cysts by introducing a follicle stimulating hormone |
| topic | modeling of functional cysts ovarian morphology functional ovarian cysts |
| url | https://bulletin.ssmu.ru/jour/article/view/964 |
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