Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2
Aims. Although altered endocrine changes following bariatric surgery in morbidly obese patients with diabetes have been demonstrated by previous studies, little is known about their effects on low BMI patients of T2DM. We investigated the changes in adipokines and sICAM-1 in Chinese subjects with lo...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/240971 |
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| author | Chandrama Shrestha Honghui He Yiqun Liu Shaihong Zhu Jing Xiong Zhaohui Mo |
| author_facet | Chandrama Shrestha Honghui He Yiqun Liu Shaihong Zhu Jing Xiong Zhaohui Mo |
| author_sort | Chandrama Shrestha |
| collection | DOAJ |
| description | Aims. Although altered endocrine changes following bariatric surgery in morbidly obese patients with diabetes have been demonstrated by previous studies, little is known about their effects on low BMI patients of T2DM. We investigated the changes in adipokines and sICAM-1 in Chinese subjects with low BMI and T2DM after LRYGB and explored their relationship with postsurgical insulin sensitivity. Methods. Plasma levels of adiponectin, sICAM-1, fasting glucose, glycated hemoglobin, and fasting insulin and serum levels of visfatin were measured before and at three months after LRYGB in 33 T2DM patients with BMI of 22–30 kg·m−2. Results. Significant reductions in anthropometric measurements and indicators of glucose and lipid metabolism and moderate reductions in insulin resistance and fasting insulin were observed at three months after LRYGB. Postoperative adiponectin level () was increased compared to the preoperative level, whereas visfatin () and sICAM-1 () were lower than that before surgery. Serum adiponectin negatively correlated with HOMA-IR and FIns both preoperatively and at three months after surgery, and visfatin positively correlated with HOMA-IR and FIns both preoperatively and postoperatively. Conclusion. Changes in adipokines were related to an improvement in postsurgical insulin sensitivity, which was predicted by weight loss after LRYGB even in low BMI patients with T2DM. |
| format | Article |
| id | doaj-art-6b135f3bc7f44acab9389b2e09cbaf64 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6b135f3bc7f44acab9389b2e09cbaf642025-02-03T01:32:13ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/240971240971Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2Chandrama Shrestha0Honghui He1Yiqun Liu2Shaihong Zhu3Jing Xiong4Zhaohui Mo5Department of Endocrinology and Metabolism, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaDepartment of Endocrinology and Metabolism, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaDepartment of Endocrinology and Metabolism, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaDepartment of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaDepartment of Endocrinology and Metabolism, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaDepartment of Endocrinology and Metabolism, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, ChinaAims. Although altered endocrine changes following bariatric surgery in morbidly obese patients with diabetes have been demonstrated by previous studies, little is known about their effects on low BMI patients of T2DM. We investigated the changes in adipokines and sICAM-1 in Chinese subjects with low BMI and T2DM after LRYGB and explored their relationship with postsurgical insulin sensitivity. Methods. Plasma levels of adiponectin, sICAM-1, fasting glucose, glycated hemoglobin, and fasting insulin and serum levels of visfatin were measured before and at three months after LRYGB in 33 T2DM patients with BMI of 22–30 kg·m−2. Results. Significant reductions in anthropometric measurements and indicators of glucose and lipid metabolism and moderate reductions in insulin resistance and fasting insulin were observed at three months after LRYGB. Postoperative adiponectin level () was increased compared to the preoperative level, whereas visfatin () and sICAM-1 () were lower than that before surgery. Serum adiponectin negatively correlated with HOMA-IR and FIns both preoperatively and at three months after surgery, and visfatin positively correlated with HOMA-IR and FIns both preoperatively and postoperatively. Conclusion. Changes in adipokines were related to an improvement in postsurgical insulin sensitivity, which was predicted by weight loss after LRYGB even in low BMI patients with T2DM.http://dx.doi.org/10.1155/2013/240971 |
| spellingShingle | Chandrama Shrestha Honghui He Yiqun Liu Shaihong Zhu Jing Xiong Zhaohui Mo Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2 International Journal of Endocrinology |
| title | Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2 |
| title_full | Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2 |
| title_fullStr | Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2 |
| title_full_unstemmed | Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2 |
| title_short | Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2 |
| title_sort | changes in adipokines following laparoscopic roux en y gastric bypass surgery in chinese individuals with type 2 diabetes mellitus and bmi of 22 30 kg·m 2 |
| url | http://dx.doi.org/10.1155/2013/240971 |
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