Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis
We compare the value of TACE to liver resection for patients with BCLC stage A and B HCC. For patients with HCC in cirrhosis LT is the treatment of choice. TACE represents the current standard for unresectable BCLC stage B patients not eligible for LT. Recently liver resection for HCC and significan...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/696120 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562051207135232 |
|---|---|
| author | Teodor Kapitanov Ulf P. Neumann Maximilian Schmeding |
| author_facet | Teodor Kapitanov Ulf P. Neumann Maximilian Schmeding |
| author_sort | Teodor Kapitanov |
| collection | DOAJ |
| description | We compare the value of TACE to liver resection for patients with BCLC stage A and B HCC. For patients with HCC in cirrhosis LT is the treatment of choice. TACE represents the current standard for unresectable BCLC stage B patients not eligible for LT. Recently liver resection for HCC and significant cirrhosis has become increasingly popular. A systematic search of the literature and meta-analysis was conducted to identify studies, reporting short- and long-term results of hepatic resection versus TACE for HCC treatment. The data were analyzed regarding the odds for 30-day mortality and hazard ratio for overall-survival. 12 studies comparing short- and long-term outcome of HR versus TACE for HCC were identified. Peri-interventional mortality and overall survival were investigated. Peri-interventional mortality was higher for surgical resection (n.s.), and overall-survival was significantly better for surgically treated patients at one year (P=0.002) and 3 years (P≤0.00001). The hazard ratio of overall-survival for all twelve studies was 0.70 (P=0.0001) and significantly in favor of surgical treatment. Although large RCTs are missing and the available data are limited and not homogeneous a reappraisal of the current treatment guidelines should be considered based on the superior long-term outcome for surgically treated patients. |
| format | Article |
| id | doaj-art-6b09cc4c2052477d800676ab7da5772a |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-6b09cc4c2052477d800676ab7da5772a2025-02-03T01:23:32ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/696120696120Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-AnalysisTeodor Kapitanov0Ulf P. Neumann1Maximilian Schmeding2Department of General, Visceral and Transplantation Surgery, University Hospital Aachen, RWTH Aachen, Pauwelstraße 30, 52074 Aachen, GermanyDepartment of General, Visceral and Transplantation Surgery, University Hospital Aachen, RWTH Aachen, Pauwelstraße 30, 52074 Aachen, GermanyDepartment of General, Visceral and Transplantation Surgery, University Hospital Aachen, RWTH Aachen, Pauwelstraße 30, 52074 Aachen, GermanyWe compare the value of TACE to liver resection for patients with BCLC stage A and B HCC. For patients with HCC in cirrhosis LT is the treatment of choice. TACE represents the current standard for unresectable BCLC stage B patients not eligible for LT. Recently liver resection for HCC and significant cirrhosis has become increasingly popular. A systematic search of the literature and meta-analysis was conducted to identify studies, reporting short- and long-term results of hepatic resection versus TACE for HCC treatment. The data were analyzed regarding the odds for 30-day mortality and hazard ratio for overall-survival. 12 studies comparing short- and long-term outcome of HR versus TACE for HCC were identified. Peri-interventional mortality and overall survival were investigated. Peri-interventional mortality was higher for surgical resection (n.s.), and overall-survival was significantly better for surgically treated patients at one year (P=0.002) and 3 years (P≤0.00001). The hazard ratio of overall-survival for all twelve studies was 0.70 (P=0.0001) and significantly in favor of surgical treatment. Although large RCTs are missing and the available data are limited and not homogeneous a reappraisal of the current treatment guidelines should be considered based on the superior long-term outcome for surgically treated patients.http://dx.doi.org/10.1155/2015/696120 |
| spellingShingle | Teodor Kapitanov Ulf P. Neumann Maximilian Schmeding Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis Gastroenterology Research and Practice |
| title | Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis |
| title_full | Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis |
| title_fullStr | Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis |
| title_full_unstemmed | Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis |
| title_short | Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis |
| title_sort | hepatocellular carcinoma in liver cirrhosis surgical resection versus transarterial chemoembolization a meta analysis |
| url | http://dx.doi.org/10.1155/2015/696120 |
| work_keys_str_mv | AT teodorkapitanov hepatocellularcarcinomainlivercirrhosissurgicalresectionversustransarterialchemoembolizationametaanalysis AT ulfpneumann hepatocellularcarcinomainlivercirrhosissurgicalresectionversustransarterialchemoembolizationametaanalysis AT maximilianschmeding hepatocellularcarcinomainlivercirrhosissurgicalresectionversustransarterialchemoembolizationametaanalysis |