Impact of lactate on immune cell function in the tumor microenvironment: mechanisms and therapeutic perspectives

Impact of lactate on immune cell function in the tumor microenvironment: mechanisms and therapeutic perspectives

Lactate has emerged as a key regulator in the tumor microenvironment (TME), influencing both tumor progression and immune dynamics. As a byproduct of aerobic glycolysis, lactate satisfies the metabolic needs of proliferating tumor cells while reshaping the TME to facilitate immune evasion. Elevated...

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Bibliographic Details
Main Authors: Xuan-Yu Gu, Jia-Li Yang, Rui Lai, Zheng-Jun Zhou, Dan Tang, Long Hu, Li-Jin Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
lactate metabolism
tumor microenvironment
immunosuppression
targeted therapy
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563303/full
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