Role of mutual regulation of microRNA and signal pathway in diabetic nephropathy
As one of the common microvascular complications of diabetes, diabetic kidney disease（DKD） is an important cause of chronic kidney disease（CKD） and end-stage kidney disease.The major pathological features of DKD include loss of podocytes, thickening of glomerular basement membrane, hypertrophy of me...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57902898&Fpath=home&index=0 |
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| author | Li Xiao-ya Ma Chan-juan Li Rong-shan |
| author_facet | Li Xiao-ya Ma Chan-juan Li Rong-shan |
| author_sort | Li Xiao-ya |
| collection | DOAJ |
| description | As one of the common microvascular complications of diabetes, diabetic kidney disease（DKD） is an important cause of chronic kidney disease（CKD） and end-stage kidney disease.The major pathological features of DKD include loss of podocytes, thickening of glomerular basement membrane, hypertrophy of mesangial cells and ultimate renal fibrosis due to a deposition of extracellular matrix.In recent years, growing evidence has shown that miRNA plays an important role in the occurrence and development of DKD.Many studies have demonstrated that miRNA could interact with signaling pathways for regulating the expression of DKD-related genes.Identifying abnormal expression of miRNA in early-stage DKD is vital for its timely diagnosis and treatment.This review summarized the effects of miRNA on the occurrence and development of DKD at the level of cell signaling pathways. |
| format | Article |
| id | doaj-art-6b02227fe1aa454c86dc09798fda8495 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2021-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-6b02227fe1aa454c86dc09798fda84952025-08-20T03:48:58ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902021-01-01211040104457902898Role of mutual regulation of microRNA and signal pathway in diabetic nephropathyLi Xiao-yaMa Chan-juanLi Rong-shanAs one of the common microvascular complications of diabetes, diabetic kidney disease（DKD） is an important cause of chronic kidney disease（CKD） and end-stage kidney disease.The major pathological features of DKD include loss of podocytes, thickening of glomerular basement membrane, hypertrophy of mesangial cells and ultimate renal fibrosis due to a deposition of extracellular matrix.In recent years, growing evidence has shown that miRNA plays an important role in the occurrence and development of DKD.Many studies have demonstrated that miRNA could interact with signaling pathways for regulating the expression of DKD-related genes.Identifying abnormal expression of miRNA in early-stage DKD is vital for its timely diagnosis and treatment.This review summarized the effects of miRNA on the occurrence and development of DKD at the level of cell signaling pathways.http://www.lcszb.com/thesisDetails?columnId=57902898&Fpath=home&index=0Diabetic kidney diseasemiRNASignaling pathway |
| spellingShingle | Li Xiao-ya Ma Chan-juan Li Rong-shan Role of mutual regulation of microRNA and signal pathway in diabetic nephropathy Linchuang shenzangbing zazhi Diabetic kidney disease miRNA Signaling pathway |
| title | Role of mutual regulation of microRNA and signal pathway in diabetic nephropathy |
| title_full | Role of mutual regulation of microRNA and signal pathway in diabetic nephropathy |
| title_fullStr | Role of mutual regulation of microRNA and signal pathway in diabetic nephropathy |
| title_full_unstemmed | Role of mutual regulation of microRNA and signal pathway in diabetic nephropathy |
| title_short | Role of mutual regulation of microRNA and signal pathway in diabetic nephropathy |
| title_sort | role of mutual regulation of microrna and signal pathway in diabetic nephropathy |
| topic | Diabetic kidney disease miRNA Signaling pathway |
| url | http://www.lcszb.com/thesisDetails?columnId=57902898&Fpath=home&index=0 |
| work_keys_str_mv | AT lixiaoya roleofmutualregulationofmicrornaandsignalpathwayindiabeticnephropathy AT machanjuan roleofmutualregulationofmicrornaandsignalpathwayindiabeticnephropathy AT lirongshan roleofmutualregulationofmicrornaandsignalpathwayindiabeticnephropathy |