Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study
Introduction: In clinical perspectives, how to distinguish a small proportion of children at risk of developing neurological complications from a large number of children with mild symptoms still remains a challenge for primary care doctors. Methodology: From January 2012 to December 2015, 225 c...
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| Format: | Article |
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The Journal of Infection in Developing Countries
2018-05-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/9845 |
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| author | Chunhua Liu Kaiyan Wang Niyang Lin Jianling Cai Binglin Cui Beiyan Wu |
| author_facet | Chunhua Liu Kaiyan Wang Niyang Lin Jianling Cai Binglin Cui Beiyan Wu |
| author_sort | Chunhua Liu |
| collection | DOAJ |
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Introduction: In clinical perspectives, how to distinguish a small proportion of children at risk of developing neurological complications from a large number of children with mild symptoms still remains a challenge for primary care doctors.
Methodology: From January 2012 to December 2015, 225 cases with severe hand, foot and mouth disease (HFMD) matched with 492 controls were enrolled in the age-matched, case-control study. Continuous variables were examined by univariate analysis using a chi-squared or Fisher’s exact test, and categorical variables were reported by relative risks (odd’s ratio). Multivariate logistic regression was used to analyze the independent risk factors for severe HFMD.
Results: Peak body temperature over 37.5℃，total duration of fever over 3 days, lethargy, enterovirus 71 (EV71) infection were independent risk factors for severe HFMD.
Conclusions: Peak body temperature over 37.5℃，total duration of fever over 3 days, lethargy, EV71 infection were independent risk factors for severe HFMD.
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| format | Article |
| id | doaj-art-6afcddff440c4f3d952060e23eab8e1d |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2018-05-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-6afcddff440c4f3d952060e23eab8e1d2025-08-20T02:14:20ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802018-05-01120510.3855/jidc.9845Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control studyChunhua Liu0Kaiyan Wang1Niyang Lin2Jianling Cai3Binglin Cui4Beiyan Wu5The First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaShantou University Medical College , Shantou, ChinaThe First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaThe First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaThe First Affiliated Hospital of Shantou University Medical College, Shantou, ChinaThe First Affiliated Hospital of Shantou University Medical College, Shantou, China Introduction: In clinical perspectives, how to distinguish a small proportion of children at risk of developing neurological complications from a large number of children with mild symptoms still remains a challenge for primary care doctors. Methodology: From January 2012 to December 2015, 225 cases with severe hand, foot and mouth disease (HFMD) matched with 492 controls were enrolled in the age-matched, case-control study. Continuous variables were examined by univariate analysis using a chi-squared or Fisher’s exact test, and categorical variables were reported by relative risks (odd’s ratio). Multivariate logistic regression was used to analyze the independent risk factors for severe HFMD. Results: Peak body temperature over 37.5℃，total duration of fever over 3 days, lethargy, enterovirus 71 (EV71) infection were independent risk factors for severe HFMD. Conclusions: Peak body temperature over 37.5℃，total duration of fever over 3 days, lethargy, EV71 infection were independent risk factors for severe HFMD. https://jidc.org/index.php/journal/article/view/9845Hand, foot and mouth diseasechildrenrisk factorenterovirusesdiagnosis |
| spellingShingle | Chunhua Liu Kaiyan Wang Niyang Lin Jianling Cai Binglin Cui Beiyan Wu Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study Journal of Infection in Developing Countries Hand, foot and mouth disease children risk factor enteroviruses diagnosis |
| title | Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study |
| title_full | Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study |
| title_fullStr | Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study |
| title_full_unstemmed | Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study |
| title_short | Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study |
| title_sort | risk factors of severe hand foot and mouth disease in shantou china a case control study |
| topic | Hand, foot and mouth disease children risk factor enteroviruses diagnosis |
| url | https://jidc.org/index.php/journal/article/view/9845 |
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