GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors.

GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors.

Bmi1 is a member of the polycomb repressive complex 1 and plays different roles during embryonic development, depending on the developmental context. Bmi1 over expression is observed in many types of cancer, including tumors of astroglial and neural origin. Although genetic depletion of Bmi1 has bee...

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Main Authors: Bart A Westerman, Marleen Blom, Ellen Tanger, Martin van der Valk, Ji-Ying Song, Marije van Santen, Jules Gadiot, Paulien Cornelissen-Steijger, John Zevenhoven, Haydn M Prosser, Anthony Uren, Eleonora Aronica, Maarten van Lohuizen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035943&type=printable
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