Adeno-associated virus vector modification based on directed evolution technology for gene therapy targeting head and neck squamous cell carcinoma

Adeno-associated virus vector modification based on directed evolution technology for gene therapy targeting head and neck squamous cell carcinoma

IntroductionAdeno-associated virus (AAV) vectors are promising tools for cancer gene therapy, yet their clinical application in head and neck squamous cell carcinoma (HNSCC) is hindered by suboptimal transduction efficiency and off-target risks. Bioengineered AAV capsids require optimization to enha...

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Bibliographic Details
Main Authors: Yiyuan Zhu, Wei Ji, Qi Zhang, Yanbo Dong, Liangfa Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
AAV
gene therapy
head and neck squamous cell carcinoma
viral vector
molecular evolution
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1566584/full
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