Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

We aimed to understand the role of G protein‐coupled receptor 4 (GPR4) in tumorigenesis. GPR4 is a pH‐sensing receptor that is activated by acidic extracellular pH. GPR4 is expressed primarily in vascular endothelial cells (ECs). Intestinal tissue from patients with inflammatory bowel disease (IBD)...

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Bibliographic Details
Main Authors: Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl deVallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Molecular Oncology
Subjects:
colorectal cancer
GPR4
inflammatory bowel disease
pH‐sensing G protein‐coupled receptors
Online Access:https://doi.org/10.1002/1878-0261.70045
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