Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancer
AimsTo investigate the expression and clinical significance of heat shock protein H1 (HSPH1) in non-small cell lung cancer (NSCLC). To provide new and reliable biomarkers for the treatment of NSCLC.Main methodsVarious public databases were used to analyse the molecular characteristics, disease relev...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1553248/full |
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| author | Rui Wang Rui Wang Rongqi Guo Rongqi Guo Tianyi Huang Yu Lu Weisong Zhang Weisong Zhang Yihao Wang Yihao Wang Qinggan Ni Jianxiang Song Jianxiang Song Xia Li |
| author_facet | Rui Wang Rui Wang Rongqi Guo Rongqi Guo Tianyi Huang Yu Lu Weisong Zhang Weisong Zhang Yihao Wang Yihao Wang Qinggan Ni Jianxiang Song Jianxiang Song Xia Li |
| author_sort | Rui Wang |
| collection | DOAJ |
| description | AimsTo investigate the expression and clinical significance of heat shock protein H1 (HSPH1) in non-small cell lung cancer (NSCLC). To provide new and reliable biomarkers for the treatment of NSCLC.Main methodsVarious public databases were used to analyse the molecular characteristics, disease relevance and expression differences of HSPH1 and to investigate the correlation between HSPH1 expression and prognosis in NSCLC patients. MsigDB and Molecular signatures database were used for enrichment analysis. The HSPH1 protein interaction network was constructed using the STRING database. In addition, immune infiltration analysis was performed. Subsequently, the expression levels of HSPH1 in Lung cancer cell lines, human NSCLC tissues and normal tissues were determined using various experiments. Finally, a retrospective analysis was performed to determine whether the expression level of HSPH1 was associated with the clinical characteristics and prognosis of NSCLC patients.ResultsThe high expression of HSPH1 in NSCLC was significantly correlated with the clinical characteristics and poor prognosis of patients, and it may affect the progression of NSCLC by forming a regulatory network with molecules such as HSPA8, BAG2, etc., and its mechanism may involve the regulation of the P53 signalling pathway, G2M_CHECKPOINT and mTORC1_SGNALING. Experiments confirmed that HSPH1 was also highly expressed in NSCLC tissues and cells.ConclusionHSPH1 can be used as a potential diagnostic and prognostic marker for NSCLC, and its involvement in NSCLC progression and immune regulation may be one of its therapeutic targets. |
| format | Article |
| id | doaj-art-6aebf6650b284074805a8fc60dfb3eca |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-6aebf6650b284074805a8fc60dfb3eca2025-08-20T03:52:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-05-011510.3389/fonc.2025.15532481553248Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancerRui Wang0Rui Wang1Rongqi Guo2Rongqi Guo3Tianyi Huang4Yu Lu5Weisong Zhang6Weisong Zhang7Yihao Wang8Yihao Wang9Qinggan Ni10Jianxiang Song11Jianxiang Song12Xia Li13Department of Thoracic Surgery, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, Jiangsu, ChinaMedical College of Nantong University, Nantong, Jiangsu, ChinaDepartment of Thoracic Surgery, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, Jiangsu, ChinaMedical College of Nantong University, Nantong, Jiangsu, ChinaMedical College of Nantong University, Nantong, Jiangsu, ChinaMedical College of Nantong University, Nantong, Jiangsu, ChinaDepartment of Thoracic Surgery, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, Jiangsu, ChinaMedical College of Nantong University, Nantong, Jiangsu, ChinaDepartment of Thoracic Surgery, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, Jiangsu, ChinaMedical College of Nantong University, Nantong, Jiangsu, ChinaDepartment of Burns and Plastic Surgery, Yancheng Clinical College of Xuzhou Medical University, The First People’s Hospital of Yancheng, Yancheng, Jiangsu, ChinaDepartment of Thoracic Surgery, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, Jiangsu, ChinaMedical College of Nantong University, Nantong, Jiangsu, ChinaDepartment of General Medicine, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, Jiangsu, ChinaAimsTo investigate the expression and clinical significance of heat shock protein H1 (HSPH1) in non-small cell lung cancer (NSCLC). To provide new and reliable biomarkers for the treatment of NSCLC.Main methodsVarious public databases were used to analyse the molecular characteristics, disease relevance and expression differences of HSPH1 and to investigate the correlation between HSPH1 expression and prognosis in NSCLC patients. MsigDB and Molecular signatures database were used for enrichment analysis. The HSPH1 protein interaction network was constructed using the STRING database. In addition, immune infiltration analysis was performed. Subsequently, the expression levels of HSPH1 in Lung cancer cell lines, human NSCLC tissues and normal tissues were determined using various experiments. Finally, a retrospective analysis was performed to determine whether the expression level of HSPH1 was associated with the clinical characteristics and prognosis of NSCLC patients.ResultsThe high expression of HSPH1 in NSCLC was significantly correlated with the clinical characteristics and poor prognosis of patients, and it may affect the progression of NSCLC by forming a regulatory network with molecules such as HSPA8, BAG2, etc., and its mechanism may involve the regulation of the P53 signalling pathway, G2M_CHECKPOINT and mTORC1_SGNALING. Experiments confirmed that HSPH1 was also highly expressed in NSCLC tissues and cells.ConclusionHSPH1 can be used as a potential diagnostic and prognostic marker for NSCLC, and its involvement in NSCLC progression and immune regulation may be one of its therapeutic targets.https://www.frontiersin.org/articles/10.3389/fonc.2025.1553248/fullHSPH1NSCLCbiomarkerbioinformatics analysisprognosisprogression |
| spellingShingle | Rui Wang Rui Wang Rongqi Guo Rongqi Guo Tianyi Huang Yu Lu Weisong Zhang Weisong Zhang Yihao Wang Yihao Wang Qinggan Ni Jianxiang Song Jianxiang Song Xia Li Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancer Frontiers in Oncology HSPH1 NSCLC biomarker bioinformatics analysis prognosis progression |
| title | Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancer |
| title_full | Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancer |
| title_fullStr | Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancer |
| title_full_unstemmed | Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancer |
| title_short | Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancer |
| title_sort | correlation of heat shock protein 1 expression with progression and prognosis of non small cell lung cancer |
| topic | HSPH1 NSCLC biomarker bioinformatics analysis prognosis progression |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1553248/full |
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