DWI-MRI: Single, Informative, and Noninvasive Technique for Prostate Cancer Diagnosis
Aim. To evaluate diffusion weighted image-MRI (DWI) as a single diagnostic noninvasive MRI technique for prostate cancer (PCa) diagnosis. Material and Methods. A prospective study was conducted between July 2008 and July 2009. Candidates patients were equal or more than 40 years old, with suspiciou...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/973450 |
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| author | Elhousseiny I. Ibrahiem Tarek Mohsen Adel M. Nabeeh Yasser Osman Ihab A. Hekal Mohamed Abou El-Ghar |
| author_facet | Elhousseiny I. Ibrahiem Tarek Mohsen Adel M. Nabeeh Yasser Osman Ihab A. Hekal Mohamed Abou El-Ghar |
| author_sort | Elhousseiny I. Ibrahiem |
| collection | DOAJ |
| description | Aim. To evaluate diffusion weighted image-MRI (DWI) as a single diagnostic noninvasive MRI technique for prostate cancer (PCa) diagnosis.
Material and Methods. A prospective study was conducted between July 2008 and July 2009. Candidates patients were equal or more than 40 years old, with suspicious digital rectal examination (more than clinical T2) or PSA >4 ng/mL. Informed consent was signed. DWI-MRI was performed at 1.5 T with a body coil combined with a spine coil in consecutive 100 cases. The histopathology of biopsies has been used as reference standard. Two examiners were evaluating MRI and TRUS, both of them were blinded regarding pathological findings. Accuracy, specificity, and sensitivity were statistically analyzed. Results. Based on pathological diagnosis: group A (cancerous); 75 cases and group B (non-cancerous); 25 cases. Mean age was 65.3 and 62.8 years in groups A and B, respectively. Mean PSA was 30.7 and 9.2 ng/mL in groups A and B, respectively. Sensitivity of DWI was 58.3% while specificity was 83.8%. Accuracy of lesion detection was 52.4–77.8% (𝑃<0.05). Moreover, DWI at ADC value 1.2×10−3 mL/sec could determine 82.4% of true positive cases (𝑃<0.05). ADC values were lower with Gleason score ≥7 (𝑃<0.05). Conclusion. DWI could represent a non invasive single diagnostic tool not only in detection and localization but also in prediction of Gleason score whenever DWI is used prior to invasive TRUS biopsy. Furthermore, targeted single biopsy could be planned after DWI to minimize patient morbidity by invasive techniques. |
| format | Article |
| id | doaj-art-6ae37b4af75a470d812cde5be21e2150 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6ae37b4af75a470d812cde5be21e21502025-08-20T03:34:00ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/973450973450DWI-MRI: Single, Informative, and Noninvasive Technique for Prostate Cancer DiagnosisElhousseiny I. Ibrahiem0Tarek Mohsen1Adel M. Nabeeh2Yasser Osman3Ihab A. Hekal4Mohamed Abou El-Ghar5Urology Department, Urology and Nephrology Center, Mansoura University, Mansoura 35516, EgyptRadiology Department, Urology and Nephrology Center, Mansoura University, Mansoura 35516, EgyptUrology Department, Urology and Nephrology Center, Mansoura University, Mansoura 35516, EgyptUrology Department, Urology and Nephrology Center, Mansoura University, Mansoura 35516, EgyptUrology Department, Urology and Nephrology Center, Mansoura University, Mansoura 35516, EgyptRadiology Department, Urology and Nephrology Center, Mansoura University, Mansoura 35516, EgyptAim. To evaluate diffusion weighted image-MRI (DWI) as a single diagnostic noninvasive MRI technique for prostate cancer (PCa) diagnosis. Material and Methods. A prospective study was conducted between July 2008 and July 2009. Candidates patients were equal or more than 40 years old, with suspicious digital rectal examination (more than clinical T2) or PSA >4 ng/mL. Informed consent was signed. DWI-MRI was performed at 1.5 T with a body coil combined with a spine coil in consecutive 100 cases. The histopathology of biopsies has been used as reference standard. Two examiners were evaluating MRI and TRUS, both of them were blinded regarding pathological findings. Accuracy, specificity, and sensitivity were statistically analyzed. Results. Based on pathological diagnosis: group A (cancerous); 75 cases and group B (non-cancerous); 25 cases. Mean age was 65.3 and 62.8 years in groups A and B, respectively. Mean PSA was 30.7 and 9.2 ng/mL in groups A and B, respectively. Sensitivity of DWI was 58.3% while specificity was 83.8%. Accuracy of lesion detection was 52.4–77.8% (𝑃<0.05). Moreover, DWI at ADC value 1.2×10−3 mL/sec could determine 82.4% of true positive cases (𝑃<0.05). ADC values were lower with Gleason score ≥7 (𝑃<0.05). Conclusion. DWI could represent a non invasive single diagnostic tool not only in detection and localization but also in prediction of Gleason score whenever DWI is used prior to invasive TRUS biopsy. Furthermore, targeted single biopsy could be planned after DWI to minimize patient morbidity by invasive techniques.http://dx.doi.org/10.1100/2012/973450 |
| spellingShingle | Elhousseiny I. Ibrahiem Tarek Mohsen Adel M. Nabeeh Yasser Osman Ihab A. Hekal Mohamed Abou El-Ghar DWI-MRI: Single, Informative, and Noninvasive Technique for Prostate Cancer Diagnosis The Scientific World Journal |
| title | DWI-MRI: Single, Informative, and Noninvasive Technique for Prostate Cancer Diagnosis |
| title_full | DWI-MRI: Single, Informative, and Noninvasive Technique for Prostate Cancer Diagnosis |
| title_fullStr | DWI-MRI: Single, Informative, and Noninvasive Technique for Prostate Cancer Diagnosis |
| title_full_unstemmed | DWI-MRI: Single, Informative, and Noninvasive Technique for Prostate Cancer Diagnosis |
| title_short | DWI-MRI: Single, Informative, and Noninvasive Technique for Prostate Cancer Diagnosis |
| title_sort | dwi mri single informative and noninvasive technique for prostate cancer diagnosis |
| url | http://dx.doi.org/10.1100/2012/973450 |
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