Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages
Abstract Backgrounds Alcoholic liver disease (ALD), a consequence of excessive alcohol consumption, is characterized by high incidence and mortality rates. Presently, there are no effective pharmacological interventions available for the treatment of ALD. Baicalin (BA), a natural flavonoid derived f...
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BMC
2025-05-01
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| Series: | Chinese Medicine |
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| Online Access: | https://doi.org/10.1186/s13020-025-01110-4 |
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| author | Sha Huang Yuhua Wang Jinjie Wen Wenjuan Ji Qiuxiang Zeng Kaili Deng Min Li Shanshan Kuang Wen Zhang Mo Chan Chuying Zhou Zhiping Lv Shaohui Huang |
| author_facet | Sha Huang Yuhua Wang Jinjie Wen Wenjuan Ji Qiuxiang Zeng Kaili Deng Min Li Shanshan Kuang Wen Zhang Mo Chan Chuying Zhou Zhiping Lv Shaohui Huang |
| author_sort | Sha Huang |
| collection | DOAJ |
| description | Abstract Backgrounds Alcoholic liver disease (ALD), a consequence of excessive alcohol consumption, is characterized by high incidence and mortality rates. Presently, there are no effective pharmacological interventions available for the treatment of ALD. Baicalin (BA), a natural flavonoid derived from the root of Scutellaria baicalensis, has exhibited notable hepatoprotective effects. Nevertheless, the mechanisms through which BA influences the interaction between suppressor of cytokine signaling 1 (SOCS1) and macrophages during hepatic immune development remain insufficiently understood. Materials and methods This study seeks to examine the regulatory effects of BA on ALD and to elucidate the relationship between SOCS1 and macrophage differentiation. Our experimental methodology involves the novel application of zebrafish as an in vivo model for ALD. To further investigate the underlying mechanisms, we employed gene knockout and overexpression techniques. Results The study demonstrates that BA substantially alleviates ALD in both in vivo and in vitro settings by upregulating SOCS1 expression in macrophages. Furthermore, we elucidated the association between SOCS1 and macrophage reprogramming. Specifically, SOCS1 knockdown led to the downregulation of CD86, CD80, and iNOS expression, whereas SOCS1 overexpression enhanced the expression of CD206, CD163, IL-4, and IL-10. Conclusion In conclusion, our findings suggest that BA attenuates ALD via the modulation of SOCS1-mediated macrophage reprogramming. |
| format | Article |
| id | doaj-art-6ad75f7e702f4c52a4b6cc3da1ef42db |
| institution | OA Journals |
| issn | 1749-8546 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj-art-6ad75f7e702f4c52a4b6cc3da1ef42db2025-08-20T01:51:36ZengBMCChinese Medicine1749-85462025-05-0120111510.1186/s13020-025-01110-4Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophagesSha Huang0Yuhua Wang1Jinjie Wen2Wenjuan Ji3Qiuxiang Zeng4Kaili Deng5Min Li6Shanshan Kuang7Wen Zhang8Mo Chan9Chuying Zhou10Zhiping Lv11Shaohui Huang12School of Traditional Chinese Medicine, Southern Medical UniversitySchool of Traditional Chinese Medicine, Southern Medical UniversitySchool of Traditional Chinese Medicine, Southern Medical UniversitySchool of Traditional Chinese Medicine, Southern Medical UniversitySchool of Traditional Chinese Medicine, Southern Medical UniversitySchool of Traditional Chinese Medicine, Southern Medical UniversitySchool of Traditional Chinese Medicine, Southern Medical UniversitySchool of Traditional Chinese Medicine, Southern Medical UniversitySchool of Traditional Chinese Medicine, Southern Medical UniversityDepartment of First Clinical Medical College, Guangdong Pharmaceutical UniversitySchool of Traditional Chinese Medicine, Southern Medical UniversitySchool of Traditional Chinese Medicine, Southern Medical UniversitySchool of Traditional Chinese Medicine, Southern Medical UniversityAbstract Backgrounds Alcoholic liver disease (ALD), a consequence of excessive alcohol consumption, is characterized by high incidence and mortality rates. Presently, there are no effective pharmacological interventions available for the treatment of ALD. Baicalin (BA), a natural flavonoid derived from the root of Scutellaria baicalensis, has exhibited notable hepatoprotective effects. Nevertheless, the mechanisms through which BA influences the interaction between suppressor of cytokine signaling 1 (SOCS1) and macrophages during hepatic immune development remain insufficiently understood. Materials and methods This study seeks to examine the regulatory effects of BA on ALD and to elucidate the relationship between SOCS1 and macrophage differentiation. Our experimental methodology involves the novel application of zebrafish as an in vivo model for ALD. To further investigate the underlying mechanisms, we employed gene knockout and overexpression techniques. Results The study demonstrates that BA substantially alleviates ALD in both in vivo and in vitro settings by upregulating SOCS1 expression in macrophages. Furthermore, we elucidated the association between SOCS1 and macrophage reprogramming. Specifically, SOCS1 knockdown led to the downregulation of CD86, CD80, and iNOS expression, whereas SOCS1 overexpression enhanced the expression of CD206, CD163, IL-4, and IL-10. Conclusion In conclusion, our findings suggest that BA attenuates ALD via the modulation of SOCS1-mediated macrophage reprogramming.https://doi.org/10.1186/s13020-025-01110-4ALDBaicalinSOCS1MacrophageReprogramming |
| spellingShingle | Sha Huang Yuhua Wang Jinjie Wen Wenjuan Ji Qiuxiang Zeng Kaili Deng Min Li Shanshan Kuang Wen Zhang Mo Chan Chuying Zhou Zhiping Lv Shaohui Huang Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages Chinese Medicine ALD Baicalin SOCS1 Macrophage Reprogramming |
| title | Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages |
| title_full | Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages |
| title_fullStr | Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages |
| title_full_unstemmed | Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages |
| title_short | Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages |
| title_sort | baicalin mitigates alcoholic associated liver disease via socs1 driven reprogramming of macrophages |
| topic | ALD Baicalin SOCS1 Macrophage Reprogramming |
| url | https://doi.org/10.1186/s13020-025-01110-4 |
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