Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis
In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in whole-exome sequencing in acute myeloid leukem...
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| Format: | Article |
| Language: | English |
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BioMed Central
2013-03-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-11-38.pdf |
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| _version_ | 1832557772838797312 |
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| author | Kye Hwa Lee Jae Hyeun Lim Ju Han Kim |
| author_facet | Kye Hwa Lee Jae Hyeun Lim Ju Han Kim |
| author_sort | Kye Hwa Lee |
| collection | DOAJ |
| description | In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in whole-exome sequencing in acute myeloid leukemia (AML). We selected 45 highly mutated genes with whole-exome sequencing in 10 normal matched samples of the AML-M2 subtype. To evaluate these genes, we performed concept lattice analysis and annotated these genes with existing knowledge databases. |
| format | Article |
| id | doaj-art-6ad4691750f24202b64df264b9a8cb77 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2013-03-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-6ad4691750f24202b64df264b9a8cb772025-02-03T02:36:01ZengBioMed CentralGenomics & Informatics1598-866X2234-07422013-03-01111384510.5808/GI.2013.11.1.3876Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice AnalysisKye Hwa Lee0Jae Hyeun Lim1Ju Han Kim2Division of Biomedical Informatics, Seoul National University Biomedical Informatics (SNUBI) and Systems Biomedical Informatics National Core Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea.Division of Biomedical Informatics, Seoul National University Biomedical Informatics (SNUBI) and Systems Biomedical Informatics National Core Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea.Division of Biomedical Informatics, Seoul National University Biomedical Informatics (SNUBI) and Systems Biomedical Informatics National Core Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea.In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in whole-exome sequencing in acute myeloid leukemia (AML). We selected 45 highly mutated genes with whole-exome sequencing in 10 normal matched samples of the AML-M2 subtype. To evaluate these genes, we performed concept lattice analysis and annotated these genes with existing knowledge databases.http://genominfo.org/upload/pdf/gni-11-38.pdfacute myeloid leukemiabiolatticeconcept lattice analysisDNA mutational analysisDNA sequence analysisoncogenes |
| spellingShingle | Kye Hwa Lee Jae Hyeun Lim Ju Han Kim Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis Genomics & Informatics acute myeloid leukemia biolattice concept lattice analysis DNA mutational analysis DNA sequence analysis oncogenes |
| title | Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis |
| title_full | Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis |
| title_fullStr | Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis |
| title_full_unstemmed | Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis |
| title_short | Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis |
| title_sort | annotation of genes having candidate somatic mutations in acute myeloid leukemia with whole exome sequencing using concept lattice analysis |
| topic | acute myeloid leukemia biolattice concept lattice analysis DNA mutational analysis DNA sequence analysis oncogenes |
| url | http://genominfo.org/upload/pdf/gni-11-38.pdf |
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