Seroprevalence of rubella and immunogenicity following rubella vaccination in adolescent girls in India
Introduction: Serologic surveys conducted in different countries indicate that rubella is a worldwide infection. Several such sero surveys conducted in India have also confirmed that 6-47% of women are susceptible to rubella infection. The current study was conducted on 1,329 female adolescents in...
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The Journal of Infection in Developing Countries
2011-11-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/1847 |
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| author | Hitt J Sharma Vasant S Padbidri Subhash V Kapre Suresh S Jadhav Rajeev M Dhere Sameer S Parekh Ashok D Dudhane Sunil D Shewale Gajanan S Namjoshi |
| author_facet | Hitt J Sharma Vasant S Padbidri Subhash V Kapre Suresh S Jadhav Rajeev M Dhere Sameer S Parekh Ashok D Dudhane Sunil D Shewale Gajanan S Namjoshi |
| author_sort | Hitt J Sharma |
| collection | DOAJ |
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Introduction: Serologic surveys conducted in different countries indicate that rubella is a worldwide infection. Several such sero surveys conducted in India have also confirmed that 6-47% of women are susceptible to rubella infection. The current study was conducted on 1,329 female adolescents in 12 districts of Maharashtra, India, to assess their serological status in terms of rubella exposure.
Methodology: After enrollment, a pre-vaccination blood sample was collected from the participants followed by rubella vaccination (R-vac). Adverse events were monitored for the next 6-8 weeks, at which time a post-vaccination sample was collected.
Results: Pre-vaccination rubella immunity was higher in the urban (80.2%) population compared to the rural (73.1%) population. Following R-vac vaccination, out of 1,159 participants who completed the study, all (100%) in the urban and 99.5% of participants in the rural area developed antibodies against rubella.
Conclusion: Substantial numbers of women reach childbearing age without immunity against rubella and thus are at a risk of passing the infection to their fetuses, who can then develop subsequent congenital defects leading to congenital rubella syndrome (CRS). An immunization policy recommending vaccination with rubella or rubella containing vaccine is highly desirable to prevent rubella and CRS.
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| format | Article |
| id | doaj-art-6acc8c883eb84367bbfa5f139a062212 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2011-11-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-6acc8c883eb84367bbfa5f139a0622122025-08-20T02:16:15ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802011-11-0151210.3855/jidc.1847Seroprevalence of rubella and immunogenicity following rubella vaccination in adolescent girls in IndiaHitt J Sharma0Vasant S Padbidri1Subhash V Kapre2Suresh S Jadhav3Rajeev M Dhere4Sameer S Parekh5Ashok D Dudhane6Sunil D Shewale7Gajanan S Namjoshi8Serum Institute of India Ltd., Pune-411028, IndiaKing Edward Memorial Hospital Research Centre, Pune-411011, IndiaSerum Institute of India Ltd., Pune-411028, IndiaSerum Institute of India Ltd., Pune-411028, IndiaSerum Institute of India Ltd., Pune-411028, IndiaSerum Institute of India Ltd., Pune-411028, IndiaKing Edward Memorial Hospital Research Centre, Pune-411011, IndiaSerum Institute of India Ltd., Pune-411028, IndiaEarlier with Serum Institute of India Ltd., Pune-411028, India Introduction: Serologic surveys conducted in different countries indicate that rubella is a worldwide infection. Several such sero surveys conducted in India have also confirmed that 6-47% of women are susceptible to rubella infection. The current study was conducted on 1,329 female adolescents in 12 districts of Maharashtra, India, to assess their serological status in terms of rubella exposure. Methodology: After enrollment, a pre-vaccination blood sample was collected from the participants followed by rubella vaccination (R-vac). Adverse events were monitored for the next 6-8 weeks, at which time a post-vaccination sample was collected. Results: Pre-vaccination rubella immunity was higher in the urban (80.2%) population compared to the rural (73.1%) population. Following R-vac vaccination, out of 1,159 participants who completed the study, all (100%) in the urban and 99.5% of participants in the rural area developed antibodies against rubella. Conclusion: Substantial numbers of women reach childbearing age without immunity against rubella and thus are at a risk of passing the infection to their fetuses, who can then develop subsequent congenital defects leading to congenital rubella syndrome (CRS). An immunization policy recommending vaccination with rubella or rubella containing vaccine is highly desirable to prevent rubella and CRS. https://jidc.org/index.php/journal/article/view/1847rubellaserological surveyimmunogenicitysafety |
| spellingShingle | Hitt J Sharma Vasant S Padbidri Subhash V Kapre Suresh S Jadhav Rajeev M Dhere Sameer S Parekh Ashok D Dudhane Sunil D Shewale Gajanan S Namjoshi Seroprevalence of rubella and immunogenicity following rubella vaccination in adolescent girls in India Journal of Infection in Developing Countries rubella serological survey immunogenicity safety |
| title | Seroprevalence of rubella and immunogenicity following rubella vaccination in adolescent girls in India |
| title_full | Seroprevalence of rubella and immunogenicity following rubella vaccination in adolescent girls in India |
| title_fullStr | Seroprevalence of rubella and immunogenicity following rubella vaccination in adolescent girls in India |
| title_full_unstemmed | Seroprevalence of rubella and immunogenicity following rubella vaccination in adolescent girls in India |
| title_short | Seroprevalence of rubella and immunogenicity following rubella vaccination in adolescent girls in India |
| title_sort | seroprevalence of rubella and immunogenicity following rubella vaccination in adolescent girls in india |
| topic | rubella serological survey immunogenicity safety |
| url | https://jidc.org/index.php/journal/article/view/1847 |
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